ESMFold2Biohub
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SKY-001Skyfall AI
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About
ESMFold2 is the successor to ESMFold, setting a new state of the art for single-sequence structure prediction and enabling the generation of new functional proteins through searching the ESMC model’s latent space. The model predicts high-resolution, all-atom 3D structures of biomolecular complexes directly from sequence, with optional multiple sequence alignment input for enhanced accuracy on challenging targets. It is designed for structure prediction using sequence and structure modalities, with ESM representations powering a series of looped folding layers and a diffusion model projecting pairwise representations to atomic-resolution predictions. ESMFold2 predicts protein structures directly from amino acid sequences and outputs comprehensive structural information, including all-atom coordinates for backbone and side chains, confidence metrics, and optional distogram predictions for detailed structural analysis.
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About
SKY-001 is Skyfall AI’s announced engineering world model for generating structured visual design plans from prompts, reference images and spatial constraints. It decomposes engineered objects into assemblies and parts, then predicts sequences of sketches and 3D construction states for each component. The model is demonstrated on computer-aided design (CAD) tasks such as reconstructing mechanical assemblies and on building information modeling (BIM) tasks such as turning building outlines and briefs into floor-plan layouts. Its hierarchical workflow supports parallel exploration of candidate designs, refinement of component geometry and planning across multiple construction steps. Skyfall AI presents SKY-001 as research for design and engineering applications, with potential extensions to other physical-design domains. The product page directs interested users to join a waitlist for access when it becomes public.
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Platforms Supported
Windows
Not Supported
Mac
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Linux
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Cloud
Supported
On-Premises
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iPhone
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iPad
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Android
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Chromebook
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Platforms Supported
Windows
Not Supported
Mac
Not Supported
Linux
Not Supported
Cloud
Supported
On-Premises
Not Supported
iPhone
Not Supported
iPad
Not Supported
Android
Not Supported
Chromebook
Not Supported
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Audience
Structural biology researchers who need fast, high-resolution protein structure prediction from sequence for analysis, exploration, and experimental planning
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Audience
Engineering and design researchers and professionals exploring CAD assembly generation and BIM floor-plan planning.
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Support
Phone Support
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24/7 Live Support
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Online
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Support
Phone Support
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24/7 Live Support
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Online
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API
Offers API
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API
Offers API
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Screenshots and Videos |
Screenshots and VideosNo images available
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Pricing
Free
Free Version
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Free Trial
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Pricing
No information available.
Free Version
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Free Trial
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Reviews/
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Reviews/
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Training
Documentation
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Webinars
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Live Online
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In Person
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Training
Documentation
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Webinars
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Live Online
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In Person
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Company InformationBiohub
Founded: 2016
United States
biohub.ai/models/esmfold2
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Company InformationSkyfall AI
Founded: 2024
United States
skyfall.ai/sky-001
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Integrations
Biohub
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Python
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