ESMFold2

ESMFold2

Biohub
SKY-001

SKY-001

Skyfall AI
+
+

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About

ESMFold2 is the successor to ESMFold, setting a new state of the art for single-sequence structure prediction and enabling the generation of new functional proteins through searching the ESMC model’s latent space. The model predicts high-resolution, all-atom 3D structures of biomolecular complexes directly from sequence, with optional multiple sequence alignment input for enhanced accuracy on challenging targets. It is designed for structure prediction using sequence and structure modalities, with ESM representations powering a series of looped folding layers and a diffusion model projecting pairwise representations to atomic-resolution predictions. ESMFold2 predicts protein structures directly from amino acid sequences and outputs comprehensive structural information, including all-atom coordinates for backbone and side chains, confidence metrics, and optional distogram predictions for detailed structural analysis.

About

SKY-001 is Skyfall AI’s announced engineering world model for generating structured visual design plans from prompts, reference images and spatial constraints. It decomposes engineered objects into assemblies and parts, then predicts sequences of sketches and 3D construction states for each component. The model is demonstrated on computer-aided design (CAD) tasks such as reconstructing mechanical assemblies and on building information modeling (BIM) tasks such as turning building outlines and briefs into floor-plan layouts. Its hierarchical workflow supports parallel exploration of candidate designs, refinement of component geometry and planning across multiple construction steps. Skyfall AI presents SKY-001 as research for design and engineering applications, with potential extensions to other physical-design domains. The product page directs interested users to join a waitlist for access when it becomes public.

Platforms Supported

Windows Not Supported
Mac Not Supported
Linux Not Supported
Cloud Supported
On-Premises Not Supported
iPhone Not Supported
iPad Not Supported
Android Not Supported
Chromebook Not Supported

Platforms Supported

Windows Not Supported
Mac Not Supported
Linux Not Supported
Cloud Supported
On-Premises Not Supported
iPhone Not Supported
iPad Not Supported
Android Not Supported
Chromebook Not Supported

Audience

Structural biology researchers who need fast, high-resolution protein structure prediction from sequence for analysis, exploration, and experimental planning

Audience

Engineering and design researchers and professionals exploring CAD assembly generation and BIM floor-plan planning.

Support

Phone Support Not Supported
24/7 Live Support Not Supported
Online Supported

Support

Phone Support Not Supported
24/7 Live Support Not Supported
Online Not Supported

API

Offers API Supported

API

Offers API Not Supported

Screenshots and Videos

Screenshots and Videos

No images available

Pricing

Free
Free Version Supported
Free Trial Not Supported

Pricing

No information available.
Free Version Not Supported
Free Trial Not Supported

Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

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Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

This software hasn't been reviewed yet. Be the first to provide a review:

Review this Software

Training

Documentation Supported
Webinars Not Supported
Live Online Not Supported
In Person Not Supported

Training

Documentation Not Supported
Webinars Not Supported
Live Online Not Supported
In Person Not Supported

Company Information

Biohub
Founded: 2016
United States
biohub.ai/models/esmfold2

Company Information

Skyfall AI
Founded: 2024
United States
skyfall.ai/sky-001

Alternatives

Alternatives

HunyuanWorld

HunyuanWorld

Tencent
ESMC

ESMC

Biohub
WorldClaw

WorldClaw

Tencent
Evo 2

Evo 2

Arc Institute
HyperProtein

HyperProtein

Hypercube

Categories

AI Models Supported
AI Science Supported

Categories

AI World Models Supported

Integrations

Biohub Supported
Python Supported

Integrations

Biohub Not Supported
Python Not Supported
Claim ESMFold2 and update features and information
Claim ESMFold2 and update features and information
Claim SKY-001 and update features and information
Claim SKY-001 and update features and information