Biohub
Biohub is an open platform for building on the world model of protein biology. It provides access to the ESM family of models, including ESMC, ESMFold2, and ESM3, along with interactive tools and developer resources for protein science research. ESMC is a state-of-the-art protein language model trained on billions of evolutionary sequences, building representations that capture fundamental mechanisms of protein structure and function. It powers functional analysis, structure prediction, protein design, and the exploration of evolutionary relationships between proteins. ESMFold2 predicts high-resolution, all-atom 3D structures of biomolecular complexes directly from sequence, with optional multiple sequence alignment input for enhanced accuracy on challenging targets. ESM3 jointly models sequence, structure, and function, enabling controllable generation of novel proteins by conditioning on any combination of these modalities.
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Claude Mythos 5
Claude Mythos 5 is Anthropic’s most advanced restricted-access AI model, designed for trusted cyberdefenders, infrastructure providers, and select research organizations. It uses the same underlying model as Claude Fable 5 but provides lifted safeguards in approved areas for specialized high-trust use cases. The model delivers exceptional capabilities in cybersecurity, software engineering, scientific research, long-context reasoning, vision, and autonomous task execution. Anthropic initially deployed Claude Mythos 5 through Project Glasswing in collaboration with the U.S. government to help protect critical software and infrastructure. The model also shows strong potential in life sciences, including protein design, molecular biology hypothesis generation, and genomics research. Claude Mythos 5 is built for organizations that need frontier AI capabilities under controlled, trusted-access conditions.
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Evo 2
Evo 2 is a genomic foundation model capable of generalist prediction and design tasks across DNA, RNA, and proteins. It utilizes a frontier deep learning architecture to model biological sequences at single-nucleotide resolution, achieving near-linear scaling of compute and memory relative to context length. Trained with 40 billion parameters and a 1 megabase context length, Evo 2 processes over 9 trillion nucleotides from diverse eukaryotic and prokaryotic genomes. This extensive training enables Evo 2 to perform zero-shot function prediction across multiple biological modalities, including DNA, RNA, and proteins, and to generate novel sequences with plausible genomic architecture. The model's capabilities have been demonstrated in tasks such as designing functional CRISPR systems and predicting disease-causing mutations in human genes. Evo 2 is publicly accessible via Arc's GitHub repository and is integrated into the NVIDIA BioNeMo framework.
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Claude Mythos 5.1
Claude Mythos 5.1 is Anthropic’s newest Mythos-class model, designed for advanced cybersecurity, biology, scientific research, coding, and long-running knowledge work. It is the same underlying model as Claude Fable 5.1 but uses different safeguards: Fable 5.1 is generally available, while Mythos 5.1 is restricted to trusted access programs with safeguards specifically designed for cybersecurity and life sciences research. The model sets a new performance frontier for agentic coding and demonstrates the strongest cyber capabilities of any Anthropic model released to date. In scientific research, Mythos 5.1 can work with specialized tools and complex workflows across molecular design, computational biology, and other technical domains. In Anthropic’s experiments, it designed high-affinity protein binders across multiple targets and achieved its strongest measured hit rate to date. It also optimized seven open-source protein and genomics deep learning models.
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