HyperProtein

Evo 2 is a genomic foundation model capable of generalist prediction and design tasks across DNA, RNA, and proteins. It utilizes a frontier deep learning architecture to model biological sequences at single-nucleotide resolution, achieving near-linear scaling of compute and memory relative to context length. Trained with 40 billion parameters and a 1 megabase context length, Evo 2 processes over 9 trillion nucleotides from diverse eukaryotic and prokaryotic genomes. This extensive training enables Evo 2 to perform zero-shot function prediction across multiple biological modalities, including DNA, RNA, and proteins, and to generate novel sequences with plausible genomic architecture. The model's capabilities have been demonstrated in tasks such as designing functional CRISPR systems and predicting disease-causing mutations in human genes. Evo 2 is publicly accessible via Arc's GitHub repository and is integrated into the NVIDIA BioNeMo framework.

Claude Mythos 5.1 is Anthropic’s newest Mythos-class model, designed for advanced cybersecurity, biology, scientific research, coding, and long-running knowledge work. It is the same underlying model as Claude Fable 5.1 but uses different safeguards: Fable 5.1 is generally available, while Mythos 5.1 is restricted to trusted access programs with safeguards specifically designed for cybersecurity and life sciences research. The model sets a new performance frontier for agentic coding and demonstrates the strongest cyber capabilities of any Anthropic model released to date. In scientific research, Mythos 5.1 can work with specialized tools and complex workflows across molecular design, computational biology, and other technical domains. In Anthropic’s experiments, it designed high-affinity protein binders across multiple targets and achieved its strongest measured hit rate to date. It also optimized seven open-source protein and genomics deep learning models.