ESMFold2

ESMFold2

Biohub
Photo51

Photo51

Fearless League
+
+

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About

ESMFold2 is the successor to ESMFold, setting a new state of the art for single-sequence structure prediction and enabling the generation of new functional proteins through searching the ESMC model’s latent space. The model predicts high-resolution, all-atom 3D structures of biomolecular complexes directly from sequence, with optional multiple sequence alignment input for enhanced accuracy on challenging targets. It is designed for structure prediction using sequence and structure modalities, with ESM representations powering a series of looped folding layers and a diffusion model projecting pairwise representations to atomic-resolution predictions. ESMFold2 predicts protein structures directly from amino acid sequences and outputs comprehensive structural information, including all-atom coordinates for backbone and side chains, confidence metrics, and optional distogram predictions for detailed structural analysis.

About

Photo51 is a web-based molecular biology suite for designing and analyzing DNA and protein sequences. It supports plasmid design, automated feature annotation, virtual cloning, PCR primer design and virtual agarose gel electrophoresis. Researchers can import sequence files and use an integrated genome browser to explore reference genomes, inspect gene views and export sequences into projects. Additional tools include guide RNA design with PAM visualization, pairwise and multiple sequence alignment, Sanger chromatogram viewing, protein alignment and reverse translation. Photo51 also provides shared team workspaces and version history for collaborative projects. Its open-access genome browser supports genome exploration, while subscriptions provide additional editing and analysis features. It is aimed at researchers, educators and biotechnology teams working with molecular biology workflows.

Platforms Supported

Windows Not Supported
Mac Not Supported
Linux Not Supported
Cloud Supported
On-Premises Not Supported
iPhone Not Supported
iPad Not Supported
Android Not Supported
Chromebook Not Supported

Platforms Supported

Windows Supported
Mac Supported
Linux Not Supported
Cloud Supported
On-Premises Not Supported
iPhone Not Supported
iPad Not Supported
Android Not Supported
Chromebook Not Supported

Audience

Structural biology researchers who need fast, high-resolution protein structure prediction from sequence for analysis, exploration, and experimental planning

Audience

For researchers, educators and biotech businesses looking for a collaborative molecular biology software suite.

Support

Phone Support Not Supported
24/7 Live Support Not Supported
Online Supported

Support

Phone Support Not Supported
24/7 Live Support Not Supported
Online Supported

API

Offers API Supported

API

Offers API Not Supported

Screenshots and Videos

Screenshots and Videos

Pricing

Free
Free Version Supported
Free Trial Not Supported

Pricing

€5/month
Academic access is €5/month; commercial use is €50/month.
Free Version Supported
Free Trial Supported

Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

This software hasn't been reviewed yet. Be the first to provide a review:

Review this Software

Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

This software hasn't been reviewed yet. Be the first to provide a review:

Review this Software

Training

Documentation Supported
Webinars Not Supported
Live Online Not Supported
In Person Not Supported

Training

Documentation Supported
Webinars Not Supported
Live Online Supported
In Person Supported

Company Information

Biohub
Founded: 2016
United States
biohub.ai/models/esmfold2

Company Information

Fearless League
Founded: 2023
Netherlands
fearlessleague.com

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Categories

AI Models Supported
AI Science Supported

Categories

Bioinformatics Supported

Integrations

Biohub Supported
Mira Supported
Python Supported

Integrations

Biohub Not Supported
Mira Not Supported
Python Not Supported
Claim ESMFold2 and update features and information
Claim ESMFold2 and update features and information
Claim Photo51 and update features and information
Claim Photo51 and update features and information