AlphaFold

AlphaFold

DeepMind
ESMFold2

ESMFold2

Biohub
+
+

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About

These exquisite, intricate machines are proteins. They underpin not just the biological processes in your body but every biological process in every living thing. They’re the building blocks of life. Currently, there are around 100 million known distinct proteins, with many more found every year. Each one has a unique 3D shape that determines how it works and what it does. But figuring out the exact structure of a protein remains an expensive and often time-consuming process, meaning we only know the exact 3D structure of a tiny fraction of the proteins known to science. Finding a way to close this rapidly expanding gap and predict the structure of millions of unknown proteins could not only help us tackle disease and more quickly find new medicines but perhaps also unlock the mysteries of how life itself works.

About

ESMFold2 is the successor to ESMFold, setting a new state of the art for single-sequence structure prediction and enabling the generation of new functional proteins through searching the ESMC model’s latent space. The model predicts high-resolution, all-atom 3D structures of biomolecular complexes directly from sequence, with optional multiple sequence alignment input for enhanced accuracy on challenging targets. It is designed for structure prediction using sequence and structure modalities, with ESM representations powering a series of looped folding layers and a diffusion model projecting pairwise representations to atomic-resolution predictions. ESMFold2 predicts protein structures directly from amino acid sequences and outputs comprehensive structural information, including all-atom coordinates for backbone and side chains, confidence metrics, and optional distogram predictions for detailed structural analysis.

Platforms Supported

Windows Not Supported
Mac Not Supported
Linux Not Supported
Cloud Supported
On-Premises Not Supported
iPhone Not Supported
iPad Not Supported
Android Not Supported
Chromebook Not Supported

Platforms Supported

Windows Not Supported
Mac Not Supported
Linux Not Supported
Cloud Supported
On-Premises Not Supported
iPhone Not Supported
iPad Not Supported
Android Not Supported
Chromebook Not Supported

Audience

Anyone looking for a Drug Discovery solution

Audience

Structural biology researchers who need fast, high-resolution protein structure prediction from sequence for analysis, exploration, and experimental planning

Support

Phone Support Not Supported
24/7 Live Support Not Supported
Online Supported

Support

Phone Support Not Supported
24/7 Live Support Not Supported
Online Supported

API

Offers API Not Supported

API

Offers API Supported

Screenshots and Videos

Screenshots and Videos

Pricing

No information available.
Free Version Not Supported
Free Trial Not Supported

Pricing

Free
Free Version Supported
Free Trial Not Supported

Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

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Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

This software hasn't been reviewed yet. Be the first to provide a review:

Review this Software

Training

Documentation Not Supported
Webinars Not Supported
Live Online Not Supported
In Person Not Supported

Training

Documentation Supported
Webinars Not Supported
Live Online Not Supported
In Person Not Supported

Company Information

DeepMind
Founded: 2010
United Kingdom
deepmind.com/research/case-studies/alphafold

Company Information

Biohub
Founded: 2016
United States
biohub.ai/models/esmfold2

Alternatives

ESMFold

ESMFold

Meta

Alternatives

ESMC

ESMC

Biohub
ESMC

ESMC

Biohub
Evo 2

Evo 2

Arc Institute
HyperProtein

HyperProtein

Hypercube

Categories

AI Science Supported
Drug Discovery Supported

Categories

AI Models Supported
AI Science Supported

Integrations

Biohub Not Supported
Complete Supported
Gemini Robotics Supported
Python Not Supported
WeatherNext Supported

Integrations

Biohub Supported
Complete Not Supported
Gemini Robotics Not Supported
Python Supported
WeatherNext Not Supported
Claim AlphaFold and update features and information
Claim AlphaFold and update features and information
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Claim ESMFold2 and update features and information