ESMFold2Biohub
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About
ESMFold2 is the successor to ESMFold, setting a new state of the art for single-sequence structure prediction and enabling the generation of new functional proteins through searching the ESMC model’s latent space. The model predicts high-resolution, all-atom 3D structures of biomolecular complexes directly from sequence, with optional multiple sequence alignment input for enhanced accuracy on challenging targets. It is designed for structure prediction using sequence and structure modalities, with ESM representations powering a series of looped folding layers and a diffusion model projecting pairwise representations to atomic-resolution predictions. ESMFold2 predicts protein structures directly from amino acid sequences and outputs comprehensive structural information, including all-atom coordinates for backbone and side chains, confidence metrics, and optional distogram predictions for detailed structural analysis.
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About
Profluent's platform revolutionizes protein design by integrating advanced AI with in-house wet-lab capabilities, enabling the creation of proteins either inspired by nature or reimagined from scratch. This holistic approach allows for precise, adaptable, and scalable solutions to complex biological challenges, delivering results that redefine what's possible with proteins. Profluent's foundation models push the frontier of protein design beyond the limitations of random discovery, facilitating the optimization of multiple attributes simultaneously, accessing greater sequence diversity, and enabling novel functionalities. By extrapolating into new protein spaces, Profluent offers unique possibilities beyond natural or patented proteins, making it cheaper, easier, and feasible for partners to achieve commercial success. Profluent's capabilities are built on a commitment to scientific rigor, leveraging diverse datasets and advanced AI to tackle challenges.
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Platforms Supported
Windows
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Mac
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Linux
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Cloud
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On-Premises
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iPhone
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iPad
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Android
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Chromebook
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Platforms Supported
Windows
Not Supported
Mac
Not Supported
Linux
Not Supported
Cloud
Supported
On-Premises
Not Supported
iPhone
Not Supported
iPad
Not Supported
Android
Not Supported
Chromebook
Not Supported
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Audience
Structural biology researchers who need fast, high-resolution protein structure prediction from sequence for analysis, exploration, and experimental planning
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Audience
Synthetic biologists seeking a solution to harness AI-driven tools for the innovative design and optimization of functional proteins
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Support
Phone Support
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24/7 Live Support
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Online
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Support
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24/7 Live Support
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Online
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API
Offers API
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API
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Pricing
Free
Free Version
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Free Trial
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Pricing
No information available.
Free Version
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Reviews/
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Training
Documentation
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Webinars
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Live Online
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In Person
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Training
Documentation
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Webinars
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Live Online
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Company InformationBiohub
Founded: 2016
United States
biohub.ai/models/esmfold2
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Company InformationProfluent
Founded: 2022
United States
www.profluent.bio/platform
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Integrations
Biohub
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Python
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