Search Results for "proteomic"
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Showing 28 open source projects for "proteomic"
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The Sashimi project hosts the Trans-Proteomic Pipeline (TPP), a mature suite of tools for mass-spec (MS, MS/MS) based proteomics: statistical validation, quantitation, visualization, and converters from raw MS data to the open mzML/mzXML formats.
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...The combined database and spectral library searching results in larger quantitation coverage, and the filter removes PSMs of larger quantitation error, retaining those of higher quantitation accuracy. The proposed pipeline is fully compatible with the Trans-Proteomic Pipeline and can be executed on Windows, Linux, and MacOS platforms.
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MScDB
A Mass Spectrometry Centric Protein Sequence Database for Proteomics
...In current database construction processes, sequence similarity clustering is used to reduce redundancies in the source data. Albeit powerful, it ignores the peptide centric nature of proteomic data and the fact that MS is able to distinguish similar sequences. Therefore, we introduce an approach that structures the protein sequence space at the peptide level using theoretical and empirical information from large-scale proteomic data to generate a mass spectrometry centric protein sequence database (MScDB). The core modules of MScDB are an in-silico proteolytic digest and a peptide centric clustering algorithm that groups protein sequences that are indistinguishable by mass spectrometry. -
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JSONVisor
Visor for mass spectrometry JSON files generated by Integrator
Visor for mass spectrometry JSON files generated by the Integrator program (Python 3 version). For more information, you can have a look at the README.md file in the source code tree: https://sourceforge.net/p/lp-csic-uab/jsonvisor3/code/ci/default/tree/README.md - Gallardo, Ó., Ovelleiro, D., Gay, M., Carrascal, M., & Abian, J. (2014). A collection of open source applications for mass spectrometry data mining. PROTEOMICS, 14(20), 2275–2279. https://doi.org/10.1002/pmic.201400124 -
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Calis-p
Estimates delta13C of species in a microbiome from proteome data
Calis-p (The CALgary approach to ISotopes in proteomics) is a java application to estimate isotopic composition (e.g. delta13C or delta15N) of individual species in a microbial community from a proteomic dataset. Calis-p 2.0 handles both natural isotope abundances and data from labelling experiments such as stable isotope probing (SIP). It requires a mzIdent (or target spectrum match) and mzML files as the input and requires about 1 min per mzML file with 10 threads and needs <10 Gb of RAM. It has been tested with data from various nano liquid chromatography/Orbitrap platforms. ... -
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Integrator
Integrates proteomic searches from multiple search engines
Perl program that integrates proteomic searches from multiple search engines, and outputs LymPHOS2 input proteomic data file. For more information, you can have a look at the README.md file in the source code tree: https://sourceforge.net/p/lp-csic-uab/integrator/code/ci/default/tree/README.md - Gallardo, Ó., Ovelleiro, D., Gay, M., Carrascal, M., & Abian, J. (2014). -
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...Here, we describe TagGraph, a computational tool that overcomes both challenges with an unrestricted string-based search method that is as much as 350-fold faster than existing approaches, and a probabilistic validation model that we optimized for PTM assignments. We applied TagGraph to a published human proteomic dataset of 25 million mass spectra and tripled confident spectrum identifications compared to its original analysis. We identified thousands of modification types on almost 1 million sites in the proteome.
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Central Proteomics Facilities Pipeline
A data analysis pipeline for shotgun mass-spectrometry proteomics.
CPFP provides a pipeline for the analysis of MS/MS proteomic data, targeted at the needs of central proteomics facilities. == Project Status - Updated January 3rd 2019 == CPFP has not been actively developed since 2014, when I left the proteomics group at UTSW. To access up-to-date algorithms for the analysis of proteomics data, other tools would now be preferred. However: * Limited fixes have been made on the main master branch by Phil Charles at the University of Oxford... -
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MS Data Miner
MS Data Miner - A web-based proteomics software
Data processing and analysis in proteomic studies is a significant challenge and very time consuming. MS Data Miner (MDM) is a freely available web-based software to analyze, process, validate, compare, and display output files from MS software, including Mascot (Matrix Science), Mascot Distiller (Matrix Science) and ProteinPilot (AB Sciex). It was developed to significantly decrease the data analysis time and to handle large proteomic studies. -
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GAPE
proteogenomic analysis software
GAPE is a one-stop proteogenomic informatics software that provides a multifaceted and standard workflow against eukaryotes in proteogenomic data-analysis cycle for genome refinement and global identification of PTM events. This software allows concurrent querying of proteomic and genomic databases to refining the genome and proteome annotations comprehensively. This includes MS data and database construction, database searches, FDR calculations, statistical result integration, validation of annotated genes, identification of previously unidentified genes, protein level identification of alternative spliced variants and SAAV, biological interpretation, and global PTM discovery. -
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A tool for extracting and preprocessing spectral count data for label-free quantitative proteomic analysis. This program is designed to be used with the Trans-Proteomic Pipeline (TPP).
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DaMold
a data mining platform for variant annotation and visualization.
...Furthermore, it cross-links each variant with more than 30 clinically relevant public databases, which contain already reported SNPs and INDELs from previous experimental studies along with associated genomic, proteomic, and clinical information. DaMold seamlessly integrates six widely used genome browser such as the UCSC genome browser, Ensembl genome browser, GWAS central genome browser, HapMap genome browser, 1000 Genomes browser, and NCBI variation viewer. Each variant is directly linked with each genome browser. DaMold can be used to analyze, elucidate, and interpret variants from data generated by NGS in clinical research. -
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Grinder is a versatile open-source bioinformatic tool to create simulated omic shotgun and amplicon sequence libraries for all main sequencing platforms.
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bictools
bictools - a package to faciliate the analysis of SAAVs using BICEPS.
bictools - a python package to perform variant detection on proteomic MS data using BICEPS (Renard et al. 2012). This repository contains a convenient KNIME workflow to perform the analysis of MS data via OpenMS and a python package (bictools) to handle results from the peptide identification from BICEPs. The combination of both utilities allows to execute the proteomic variant detection workflow. -
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Automated Proteomics Pipeline
A front end for several popular open source proteomics tools
APP automates and allows distributed computing of common proteomics tasks using a java-front end to provide both GUI and server parts. It is highly recommended for use with the Trans Proteomic Pipeline but this is not a requirement. -
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luciphor
Calculates phospho-site localizations
Luciphor is a program that performs phospho-site localization on MS/MS data processed by the Trans-Proteomic Pipeline (TPP). It is the first phospho-site prediction program to provide estimates for the false localization rate (FLR). The program is multithreaded and written in C++ for linux. -
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ConoSorter
A Large-scale Cone Snail Transcriptome/Proteome Analysis Program
ConoSorter is a high-throughput standalone program that implements regular expressions and profile Hidden Markov Models (pHMMs) for large-scale identification and classification of precursor conopeptides into gene superfamilies and classes based on the ER signal, pro-, and mature conopeptide regions generated from raw next-generation transcriptomic or proteomic data. ConoSorter also generates a set of relevant additional information (frequency of protein sequences, length, number of cysteine residues, hydrophobicity rate of N-terminal region) and automatically searches ConoServer database to allow the user to assess the reliability and relevance of the results and to aid the identification of new conopeptide superfamilies and classes. -
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Java Proteomic Library
A java proteomic development toolkit.
The JPL project is no longer updated and maintained. It has evolved after being completely reengineered and upgraded. The new project is available at http://mzjava.expasy.org. -
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FunSys, a software that can be used to analyse differential expression data from RNAseq and can integrate these analyses with data from proteomic studies.
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inhibitomev1
A systems-level host-factor survey of viral proteins that modulate inn
Viral gene products that modulate the cellular antiviral immune response targets of such viral proteins are often not known. We performed a functional proteomic approach to identify cellular binding partners of viral innate immune modulators. We used a Tet-on system to express such viral proteins in HEK293 cells and isolated protein complexes by tandem affinity purification. Altogether, we used 70 viral proteins (from 30 viruses) resulting in identification of 579 unique host proteins. ... -
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Linking BPA with RDA
This software system enables publication of ISA-Tab files to RDA.
BioPlatforms Australia (BPA) has funded a number of datasets generation initiatives around important research themes and scientific challenges faced by Australian researchers to provide a unique public resource for the benefit of Australian life sciences research. These large scale genomic, proteomic and metabolomic datasets are being generated and centrally managed by Bioplatforms Australia in collaboration with leading scientists, research institutes and government agencies. With the support of ANDS, QFAB has developed this web application to enable the publication of these datasets to Research Data Australia (RDA). By login in, BPA can upload ISA-Tab descriptions of their studies and can edit, manage and publish their collection descriptions to Research Data Australia. -
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ProteoConnections is a bioinformatics platform tailored to address the pressing needs of proteomic analyses. Organise identifications, evaluate the the acquired dataset and accelerate biological interpretation using bioinformatics applications.
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Unison is a database and web interface of integrated, precomputed proteomic predictions for rapid feature-based mining, sequence analysis, and hypothesis generation. Click "Home Page" for more information and to access the public access version.
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This program parses data out of the interact*.xml files generated by the Trans-Proteomic Pipeline (TPP). It reads in a folder of such files and either makes a tab-delimited file or loads the data into a MySQL database.
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Genome Expression Pathway Analysis Tool - Analysis and Visualization of Microarray Gene Expression Data under Genomic, Proteomic and Metabolic Context
