Best Patch Management Software for Microsoft 365
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Compare the Top Patch Management Software that integrates with Microsoft 365 as of November 2025
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This a list of Patch Management software that integrates with Microsoft 365. Use the filters on the left to add additional filters for products that have integrations with Microsoft 365. View the products that work with Microsoft 365 in the table below.
What is Patch Management Software for Microsoft 365?
Patch management software is designed to automate the process of identifying, acquiring, testing, and deploying updates (patches) to software applications, operating systems, and firmware. These patches typically fix security vulnerabilities, resolve bugs, or improve performance. Patch management tools centralize this process across an organization’s IT infrastructure, ensuring systems remain compliant and protected against threats. Many platforms integrate with vulnerability scanners, compliance frameworks, and reporting dashboards to provide visibility and control. By streamlining updates, patch management software reduces risk, improves system stability, and minimizes downtime for IT teams. Compare and read user reviews of the best Patch Management software for Microsoft 365 currently available using the table below. This list is updated regularly.
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1
EZO AssetSonar
EZO
AssetSonar’s Patch Management keeps your IT environment secure by detecting vulnerabilities across Windows, macOS, and Linux devices in real time. Agent-based monitoring identifies risks and maps them directly to affected hardware and software, while prioritized patch recommendations help IT teams focus on what matters most. You can deploy or schedule patches at scale, track success and failure rates, and ensure compliance to standards like NIST with built-in dashboards. By integrating patching into its broader ITAM workflows, AssetSonar eliminates blind spots, reduces manual effort, and gives IT leaders confidence that every endpoint is protected and audit-ready. -
2
Iru
Iru (formerly Kandji)
Iru (formerly Kandji) is an all-in-one, AI-powered security and compliance platform designed to simplify IT management and strengthen enterprise protection. Built on the Iru Context Model, it unifies identity, endpoint, and compliance into a single intelligent system that understands users, devices, and applications in context. With passwordless workforce identity, advanced endpoint detection, and automated compliance, Iru delivers both security and efficiency without the complexity of multiple tools. Its integrated approach enables IT teams to secure access, prevent threats, and maintain continuous audit readiness—all from one intuitive platform. Trusted by over 5,000 companies including Plaid, Notion, Airbus, and Vercel, Iru transforms how modern businesses manage digital trust. The result is reduced IT workload, improved employee experience, and enterprise-grade protection built for the AI era. -
3
SysAid
SysAid Technologies
SysAid is an AI-first Help Desk & ITSM platform powered by Agentic AI. It makes your IT team 100x more impactful, resolves issues faster, eliminates repetitive tasks, and shifts from firefighting to delivering strategic impact. With no-code workflows, AI-powered ticket handling, and an intuitive self-service portal, SysAid empowers IT to focus on what really matters: business value. At its core is Agentic AI: a powerful operational layer where AI Agents take the first action, accelerating resolution and boosting efficiency. Built for IT, SysAid includes enterprise-grade security, built-in governance, and the ability to add guardrails, control, and responsible AI protection to your data. Go live in weeks with fast, code-free onboarding—no heavy migrations or steep learning curves. With flexible customization and award-winning support, SysAid grows with you. ITSM run by AI—and by you. -
4
KACE by Quest
Quest Software
KACE® by Quest supports your unified endpoint management (UEM) strategy by helping you discover and track every device in your environment, automate administrative tasks, keep compliance requirements up-to-date and secure your network from a range of cyberthreats. Discover, manage and secure all your endpoints from one console as you co-manage your traditional and modern endpoints, including Windows, Mac, Linux, ChromeOS, and iOS and Android devices. KACE is a Unified Endpoint Management solution that offers a single point of control for managing IT systems across the entire organization, inside or outside your network. This comprehensive solution takes the stress out of keeping devices secure and compliant so you can do more.Starting Price: As low as $3/mo/device -
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ManageEngine Patch Manager Plus
ManageEngine
Keep all your production businesses up to date by automating the entire patching process using Patch Manager Plus. Available as both cloud-based and on-premise software, Patch Manager Plus offers features that include scanning for and detecting missing patches, automated scheduled patch deployments, test and approve patches, patch tracking, patch compliance and reporting. Patch Manager Plus also enables users to provide detailed audit and compliance reports.Starting Price: $245 per year -
6
Fleetsmith
Apple
Put your devices on auto-pilot. Fleetsmith automates device setup, intelligence, patching, and security, for your company’s Macs, iPhones, iPads, and Apple TVs. Automatically set up devices for new hires? Check. Automatically detect and prevent problems across your fleet? Yup. Automatically install and update apps automatically? You bet. Security is deeply considered in every aspect of our product, and in every decision we make. Stemming from our company value “Secure by Design,” we made sure that our product was secure from day one, and that our internal policies were secure from the get-go. Experience one click sign-up, automatic Single Sign-On (SSO), and 1-click import of your employee directory. All with zero configuration.Starting Price: $8.25 per user per month -
7
ESET PROTECT Elite
ESET
ESET PROTECT Elite is an enterprise-grade cybersecurity solution that integrates extended detection and response with comprehensive multilayered protection. It offers advanced threat defense using adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis to prevent zero-day threats and ransomware. The platform includes modern endpoint protection for computers and smartphones, server security for real-time data protection, and mobile threat defense. It also features full disk encryption, helping organizations comply with data protection regulations. ESET PROTECT Elite provides robust email security, including anti-phishing, anti-malware, and anti-spam technologies, along with cloud app protection for Microsoft 365 and Google Workspace. Vulnerability and patch management capabilities allow for automatic tracking and patching of vulnerabilities across all endpoints.Starting Price: $275 one-time payment -
8
Juriba Enterprise
Juriba
Discover the power of centralising your Digital Workplace management with the Juriba Platform. As the leading Digital Platform Conductor (DPC) tailored to the intricate demands of large enterprise Digital Workplace leaders, Juriba offers a comprehensive suite of tools. From complete Digital Workplace management and application testing and packaging to facilitating complex IT transformations and ongoing Evergreen IT management initiatives, our platform empowers you to streamline operations efficiently. Seamlessly integrating with Hybrid Digital Infrastructure Management tools like Microsoft Endpoint Manager, Microsoft Intune, ServiceNow, NexThink, and Workspace ONE, among others, Juriba synchronizes data across your entire Digital Workplace, granting you unparalleled visibility and control. Through intelligent workplace automation and orchestration, tedious tasks are eliminated, minimising human error and enhancing productivity. -
9
Enable automated processes for patch assessment, monitoring, and remediation. Apply patches up to 13 times faster without burdening your staff. Team workspaces enable you to create digital offices where local and global team members can gather online to coordinate their efforts. Monitor patch compliance, quickly identify and assess vulnerabilities, and automatically apply updates and patches to meet pre-defined standards. Patch Management watches your back, patching everything you’ve got on your network 24 hours a day, without the need for human intervention. With its unique policy-based approach, you set up the policies, define the actions, and then sit back and let ZENworks do the rest. ZENworks Patch Management includes fast, automatic patch deployment based on predefined policies, as well as the ability to customize tested patches as needed. It also supports phased rollouts to ensure smooth, error-free patch deployments to large numbers of systems.
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10
Datto RMM
Datto, a Kaseya company
Datto RMM is a secure, reliable and modern cloud-based remote monitoring and management platform that gives MSPs the ability to securely and reliably manage their customers IT infrastructures. Built to remove complexity, costs, and risks, it includes powerful automation and monitoring tools such as ransomware detection, patch management, and remote control takeover to help MSPs proactively prevent IT issues, respond faster to incidents, and deliver a better service to their customers. Protect and quickly restore PCs with reliable, image-based, all-in-one cloud backup and disaster recovery. Cloud-to-cloud backup and fast recovery for critical data in Microsoft 365 and G Suite applications. Fast and easy file and folder backup and restore with support for Windows and Mac. Safe file sync and share with a centrally managed, secure collaboration platform. Protect and quickly restore servers with reliable, image-based, all-in-one business continuity and disaster recovery.
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