ESMFold2

ESMFold2

Biohub
+
+

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About

ESMFold2 is the successor to ESMFold, setting a new state of the art for single-sequence structure prediction and enabling the generation of new functional proteins through searching the ESMC model’s latent space. The model predicts high-resolution, all-atom 3D structures of biomolecular complexes directly from sequence, with optional multiple sequence alignment input for enhanced accuracy on challenging targets. It is designed for structure prediction using sequence and structure modalities, with ESM representations powering a series of looped folding layers and a diffusion model projecting pairwise representations to atomic-resolution predictions. ESMFold2 predicts protein structures directly from amino acid sequences and outputs comprehensive structural information, including all-atom coordinates for backbone and side chains, confidence metrics, and optional distogram predictions for detailed structural analysis.

About

OpenAI's deep research is an AI-powered tool designed to autonomously conduct complex, multi-step research tasks across various domains, such as science, coding, and mathematics. By analyzing user-provided inputs—such as questions, text documents, images, PDFs, or spreadsheets—the system formulates a structured research plan, gathers relevant information, and delivers comprehensive responses within minutes. It also provides process summaries with citations, helping users verify sources. While this tool significantly accelerates research efficiency, it may occasionally produce inaccuracies or struggle to differentiate between authoritative sources and misinformation. Currently available to ChatGPT Pro users, deep research represents a step toward AI-driven knowledge discovery, with ongoing improvements planned for accuracy and response time.

Platforms Supported

Windows
Mac
Linux
Cloud
On-Premises
iPhone
iPad
Android
Chromebook

Platforms Supported

Windows
Mac
Linux
Cloud
On-Premises
iPhone
iPad
Android
Chromebook

Audience

Structural biology researchers who need fast, high-resolution protein structure prediction from sequence for analysis, exploration, and experimental planning

Audience

Researchers, professionals, and knowledge workers seeking AI-powered assistance for complex, multi-step research tasks across various domains

Support

Phone Support
24/7 Live Support
Online

Support

Phone Support
24/7 Live Support
Online

API

Offers API

API

Offers API

Screenshots and Videos

Screenshots and Videos

Pricing

Free
Free Version
Free Trial

Pricing

No information available.
Free Version
Free Trial

Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

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Reviews/Ratings

Overall 5.0 / 5
ease 5.0 / 5
features 5.0 / 5
design 5.0 / 5
support 5.0 / 5

Training

Documentation
Webinars
Live Online
In Person

Training

Documentation
Webinars
Live Online
In Person

Company Information

Biohub
Founded: 2016
United States
biohub.ai/models/esmfold2

Company Information

OpenAI
Founded: 2015
United States
openai.com/index/introducing-deep-research/

Alternatives

Alternatives

ARI

ARI

You.com
ESMC

ESMC

Biohub
Claude Research

Claude Research

Anthropic
DeepSeek R1

DeepSeek R1

DeepSeek
Evo 2

Evo 2

Arc Institute
HyperProtein

HyperProtein

Hypercube

Categories

Categories

Integrations

Biohub
ChatGPT
ChatGPT Enterprise
ChatGPT Plus
ChatGPT Pro
GPT-4o
GitHub
Microsoft 365 Copilot Analyst
Microsoft 365 Copilot Researcher
Microsoft OneDrive
Microsoft SharePoint
OpenAI
OpenAI o1
OpenAI o1-mini
OpenAI o1-pro
OpenAI o3-mini
OpenAI o3-mini-high
Python

Integrations

Biohub
ChatGPT
ChatGPT Enterprise
ChatGPT Plus
ChatGPT Pro
GPT-4o
GitHub
Microsoft 365 Copilot Analyst
Microsoft 365 Copilot Researcher
Microsoft OneDrive
Microsoft SharePoint
OpenAI
OpenAI o1
OpenAI o1-mini
OpenAI o1-pro
OpenAI o3-mini
OpenAI o3-mini-high
Python
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Claim OpenAI deep research and update features and information