ESMFold2Biohub
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About
ESMFold2 is the successor to ESMFold, setting a new state of the art for single-sequence structure prediction and enabling the generation of new functional proteins through searching the ESMC model’s latent space. The model predicts high-resolution, all-atom 3D structures of biomolecular complexes directly from sequence, with optional multiple sequence alignment input for enhanced accuracy on challenging targets. It is designed for structure prediction using sequence and structure modalities, with ESM representations powering a series of looped folding layers and a diffusion model projecting pairwise representations to atomic-resolution predictions. ESMFold2 predicts protein structures directly from amino acid sequences and outputs comprehensive structural information, including all-atom coordinates for backbone and side chains, confidence metrics, and optional distogram predictions for detailed structural analysis.
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About
Genome Computer turns your genetic data into a portable, AI-ready .genome bundle you can download, keep, self-host, and explore with Genome Intelligence, Codex, Claude Code, Cursor, or any compatible tool. The open format restructures the same underlying data found in a VCF into a structured, queryable bundle, with variants stored in fast columnar tables alongside trait associations, supporting research, gene-level context, polygenic scores, pharmacogenomics, and clear provenance. Whole-genome sequencing orders are built from gVCF data, preserving both detected variants and confidently sequenced regions where no variant was found, while FASTQ files are available on request. Existing VCF or TXT files from other providers can also be converted, imputed where needed, annotated, scored, and prepared for AI interpretation. Genome Intelligence lets you ask questions grounded in your actual genetic data, compare new research with your genotypes, and explore genetics.
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Platforms Supported
Windows
Mac
Linux
Cloud
On-Premises
iPhone
iPad
Android
Chromebook
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Platforms Supported
Windows
Mac
Linux
Cloud
On-Premises
iPhone
iPad
Android
Chromebook
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Audience
Structural biology researchers who need fast, high-resolution protein structure prediction from sequence for analysis, exploration, and experimental planning
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Audience
Individuals and developers seeking to privately explore genomic data and generate AI-powered insights without surrendering control of their genetic information
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Support
Phone Support
24/7 Live Support
Online
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Support
Phone Support
24/7 Live Support
Online
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API
Offers API
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API
Offers API
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Pricing
Free
Free Version
Free Trial
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Pricing
$15 per month
Free Version
Free Trial
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Reviews/
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Reviews/
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Training
Documentation
Webinars
Live Online
In Person
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Training
Documentation
Webinars
Live Online
In Person
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Company InformationBiohub
Founded: 2016
United States
biohub.ai/models/esmfold2
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Company InformationGenome Computer
United States
genome.computer/
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