ESMC

ESMC

Biohub
+
+

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About

ESMC is the latest in the ESM family of protein language models, establishing a new frontier in representation learning for protein biology. Trained on billions of evolutionary sequences, it learns representations that reflect a mechanistic reduction of protein structure and function. The model is built on a transformer architecture, supports sequences as its core modality, and is trained on up to 6 billion proteins. ESMC is designed for protein science research, including structure prediction, function annotation, protein design, and understanding evolutionary relationships between proteins. It can generate novel proteins from partial sequence, structure, or functional constraints, helping researchers explore new possibilities in protein design and biological discovery. The Biohub Platform provides access to ESMC through the API and the ESM Python package, with quickstart resources for installing the package, creating an API key, connecting to the platform.

About

NVIDIA PhysicsNeMo is an open source Python deep-learning framework for building, training, fine-tuning, and inferring physics-AI models that combine physics knowledge with data to accelerate simulations, create high-fidelity surrogate models, and enable near-real-time predictions across domains such as computational fluid dynamics, structural mechanics, electromagnetics, weather and climate, and digital twin applications. It provides scalable, GPU-accelerated tools and Python APIs built on PyTorch and released under the Apache 2.0 license, offering curated model architectures including physics-informed neural networks, neural operators, graph neural networks, and generative AI–based approaches so developers can harness physics-driven causality alongside observed data for engineering-grade modeling. PhysicsNeMo includes end-to-end training pipelines from geometry ingestion to differential equations, reference application recipes to jump-start workflows.

Platforms Supported

Windows Not Supported
Mac Not Supported
Linux Not Supported
Cloud Supported
On-Premises Not Supported
iPhone Not Supported
iPad Not Supported
Android Not Supported
Chromebook Not Supported

Platforms Supported

Windows Not Supported
Mac Not Supported
Linux Not Supported
Cloud Supported
On-Premises Not Supported
iPhone Not Supported
iPad Not Supported
Android Not Supported
Chromebook Not Supported

Audience

Protein science researchers who need transformer-based sequence representations for structure prediction, function annotation, mutation analysis, and protein design

Audience

Researchers, engineers, and developers who need an open source Python AI framework to build, train, fine-tune, and deploy physics-informed machine learning models for simulation, digital twins, and real-time prediction

Support

Phone Support Not Supported
24/7 Live Support Not Supported
Online Supported

Support

Phone Support Supported
24/7 Live Support Not Supported
Online Supported

API

Offers API Supported

API

Offers API Supported

Screenshots and Videos

Screenshots and Videos

Pricing

Free
Free Version Supported
Free Trial Not Supported

Pricing

Free
Free Version Supported
Free Trial Not Supported

Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

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Review this Software

Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

This software hasn't been reviewed yet. Be the first to provide a review:

Review this Software

Training

Documentation Supported
Webinars Not Supported
Live Online Not Supported
In Person Not Supported

Training

Documentation Supported
Webinars Supported
Live Online Supported
In Person Not Supported

Company Information

Biohub
Founded: 2016
United States
biohub.ai/models/esmc

Company Information

NVIDIA
Founded: 1993
United States
developer.nvidia.com/physicsnemo

Alternatives

Alternatives

Evo 2

Evo 2

Arc Institute
Alchemite

Alchemite

Intellegens
ESMFold2

ESMFold2

Biohub
NeuralWing

NeuralWing

Emmi AI
HyperProtein

HyperProtein

Hypercube
FEATool Multiphysics

FEATool Multiphysics

Precise Simulation

Categories

AI Models Supported
AI Science Supported

Categories

AI Science Supported

Integrations

Python Supported
Biohub Supported
PyTorch Not Supported

Integrations

Python Supported
Biohub Not Supported
PyTorch Supported
Claim ESMC and update features and information
Claim ESMC and update features and information
Claim NVIDIA PhysicsNeMo and update features and information
Claim NVIDIA PhysicsNeMo and update features and information