ESMFold2

ESMFold2

Biohub
+
+

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About

Differential Bio is a virtual scale-up platform for bioprocess optimization that makes microbial growth more predictable, scalable, and cost-effective through robotic lab automation and AI-driven insights. Its workflow begins with automated, high-throughput experiments that mimic large-scale stress factors in microliter environments and generate industry-relevant wet-lab data through liquid handling, fermentation, and measurement. Specialized AI models use that data to predict outcomes such as biomass growth, protein expression, cell viability, titer, production rate, yield, and cost. Through the web-based platform, teams can configure optimization goals and parameter ranges, run unlimited in-silico experiments, compare simulated fermentation outcomes, perform multi-objective optimization, and identify process conditions to implement at scale.

About

ESMFold2 is the successor to ESMFold, setting a new state of the art for single-sequence structure prediction and enabling the generation of new functional proteins through searching the ESMC model’s latent space. The model predicts high-resolution, all-atom 3D structures of biomolecular complexes directly from sequence, with optional multiple sequence alignment input for enhanced accuracy on challenging targets. It is designed for structure prediction using sequence and structure modalities, with ESM representations powering a series of looped folding layers and a diffusion model projecting pairwise representations to atomic-resolution predictions. ESMFold2 predicts protein structures directly from amino acid sequences and outputs comprehensive structural information, including all-atom coordinates for backbone and side chains, confidence metrics, and optional distogram predictions for detailed structural analysis.

Platforms Supported

Windows
Mac
Linux
Cloud
On-Premises
iPhone
iPad
Android
Chromebook

Platforms Supported

Windows
Mac
Linux
Cloud
On-Premises
iPhone
iPad
Android
Chromebook

Audience

Precision-fermentation process scientists who need to optimize microbial production and reduce uncertainty before industrial scale-up

Audience

Structural biology researchers who need fast, high-resolution protein structure prediction from sequence for analysis, exploration, and experimental planning

Support

Phone Support
24/7 Live Support
Online

Support

Phone Support
24/7 Live Support
Online

API

Offers API

API

Offers API

Screenshots and Videos

Screenshots and Videos

Pricing

No information available.
Free Version
Free Trial

Pricing

Free
Free Version
Free Trial

Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

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Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

This software hasn't been reviewed yet. Be the first to provide a review:

Review this Software

Training

Documentation
Webinars
Live Online
In Person

Training

Documentation
Webinars
Live Online
In Person

Company Information

Differential Bio
Germany
www.differential.bio/

Company Information

Biohub
Founded: 2016
United States
biohub.ai/models/esmfold2

Alternatives

Alternatives

ESMC

ESMC

Biohub
ESMC

ESMC

Biohub
Evo 2

Evo 2

Arc Institute
Evo 2

Evo 2

Arc Institute
HyperProtein

HyperProtein

Hypercube

Categories

Categories

Integrations

Biohub
Python

Integrations

Biohub
Python
Claim Differential Bio and update features and information
Claim Differential Bio and update features and information
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