ESMC

ESMC

Biohub
+
+

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About

Differential Bio is a virtual scale-up platform for bioprocess optimization that makes microbial growth more predictable, scalable, and cost-effective through robotic lab automation and AI-driven insights. Its workflow begins with automated, high-throughput experiments that mimic large-scale stress factors in microliter environments and generate industry-relevant wet-lab data through liquid handling, fermentation, and measurement. Specialized AI models use that data to predict outcomes such as biomass growth, protein expression, cell viability, titer, production rate, yield, and cost. Through the web-based platform, teams can configure optimization goals and parameter ranges, run unlimited in-silico experiments, compare simulated fermentation outcomes, perform multi-objective optimization, and identify process conditions to implement at scale.

About

ESMC is the latest in the ESM family of protein language models, establishing a new frontier in representation learning for protein biology. Trained on billions of evolutionary sequences, it learns representations that reflect a mechanistic reduction of protein structure and function. The model is built on a transformer architecture, supports sequences as its core modality, and is trained on up to 6 billion proteins. ESMC is designed for protein science research, including structure prediction, function annotation, protein design, and understanding evolutionary relationships between proteins. It can generate novel proteins from partial sequence, structure, or functional constraints, helping researchers explore new possibilities in protein design and biological discovery. The Biohub Platform provides access to ESMC through the API and the ESM Python package, with quickstart resources for installing the package, creating an API key, connecting to the platform.

Platforms Supported

Windows Not Supported
Mac Not Supported
Linux Not Supported
Cloud Supported
On-Premises Not Supported
iPhone Not Supported
iPad Not Supported
Android Not Supported
Chromebook Not Supported

Platforms Supported

Windows Not Supported
Mac Not Supported
Linux Not Supported
Cloud Supported
On-Premises Not Supported
iPhone Not Supported
iPad Not Supported
Android Not Supported
Chromebook Not Supported

Audience

Precision-fermentation process scientists who need to optimize microbial production and reduce uncertainty before industrial scale-up

Audience

Protein science researchers who need transformer-based sequence representations for structure prediction, function annotation, mutation analysis, and protein design

Support

Phone Support Not Supported
24/7 Live Support Not Supported
Online Supported

Support

Phone Support Not Supported
24/7 Live Support Not Supported
Online Supported

API

Offers API Not Supported

API

Offers API Supported

Screenshots and Videos

Screenshots and Videos

Pricing

No information available.
Free Version Not Supported
Free Trial Not Supported

Pricing

Free
Free Version Supported
Free Trial Not Supported

Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

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Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

This software hasn't been reviewed yet. Be the first to provide a review:

Review this Software

Training

Documentation Supported
Webinars Not Supported
Live Online Supported
In Person Not Supported

Training

Documentation Supported
Webinars Not Supported
Live Online Not Supported
In Person Not Supported

Company Information

Differential Bio
Germany
www.differential.bio/

Company Information

Biohub
Founded: 2016
United States
biohub.ai/models/esmc

Alternatives

Alternatives

Evo 2

Evo 2

Arc Institute
ESMC

ESMC

Biohub
ESMFold2

ESMFold2

Biohub
Evo 2

Evo 2

Arc Institute
HyperProtein

HyperProtein

Hypercube

Categories

AI Science Supported

Categories

AI Models Supported
AI Science Supported

Integrations

Biohub Not Supported
Python Not Supported

Integrations

Biohub Supported
Python Supported
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Claim Differential Bio and update features and information
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