ESMCBiohub
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About
Differential Bio is a virtual scale-up platform for bioprocess optimization that makes microbial growth more predictable, scalable, and cost-effective through robotic lab automation and AI-driven insights. Its workflow begins with automated, high-throughput experiments that mimic large-scale stress factors in microliter environments and generate industry-relevant wet-lab data through liquid handling, fermentation, and measurement. Specialized AI models use that data to predict outcomes such as biomass growth, protein expression, cell viability, titer, production rate, yield, and cost. Through the web-based platform, teams can configure optimization goals and parameter ranges, run unlimited in-silico experiments, compare simulated fermentation outcomes, perform multi-objective optimization, and identify process conditions to implement at scale.
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About
ESMC is the latest in the ESM family of protein language models, establishing a new frontier in representation learning for protein biology. Trained on billions of evolutionary sequences, it learns representations that reflect a mechanistic reduction of protein structure and function. The model is built on a transformer architecture, supports sequences as its core modality, and is trained on up to 6 billion proteins. ESMC is designed for protein science research, including structure prediction, function annotation, protein design, and understanding evolutionary relationships between proteins. It can generate novel proteins from partial sequence, structure, or functional constraints, helping researchers explore new possibilities in protein design and biological discovery. The Biohub Platform provides access to ESMC through the API and the ESM Python package, with quickstart resources for installing the package, creating an API key, connecting to the platform.
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Platforms Supported
Windows
Not Supported
Mac
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Linux
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Cloud
Supported
On-Premises
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iPhone
Not Supported
iPad
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Android
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Chromebook
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Platforms Supported
Windows
Not Supported
Mac
Not Supported
Linux
Not Supported
Cloud
Supported
On-Premises
Not Supported
iPhone
Not Supported
iPad
Not Supported
Android
Not Supported
Chromebook
Not Supported
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Audience
Precision-fermentation process scientists who need to optimize microbial production and reduce uncertainty before industrial scale-up
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Audience
Protein science researchers who need transformer-based sequence representations for structure prediction, function annotation, mutation analysis, and protein design
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Support
Phone Support
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24/7 Live Support
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Online
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Support
Phone Support
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24/7 Live Support
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Online
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API
Offers API
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API
Offers API
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Pricing
No information available.
Free Version
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Free Trial
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Pricing
Free
Free Version
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Free Trial
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Reviews/
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Reviews/
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Training
Documentation
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Webinars
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Live Online
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In Person
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Training
Documentation
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Webinars
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Live Online
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In Person
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Company InformationDifferential Bio
Germany
www.differential.bio/
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Company InformationBiohub
Founded: 2016
United States
biohub.ai/models/esmc
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Integrations
Biohub
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Python
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