S/R Bio-Informatics Software

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Browse free open source S/R Bio-Informatics Software and projects below. Use the toggles on the left to filter open source S/R Bio-Informatics Software by OS, license, language, programming language, and project status.

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  • 1
    We are developing data standards and software tools that implement these standards to develop a systemic approach to modeling, capturing, analyzing and disseminating flow cytometry data.
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    Downloads: 16 This Week
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  • 2
    SPINA

    SPINA

    Structure parameter inference approach for endocrine feedback control

    SPINA is software for the rapid, reliable and accurate determination of constant structure parameters of endocrine feedback control systems. It is a class of static function tests that require nothing more than steady-state concentrations of hormones or metabolites obtained in vivo. The first version of this cybernetic approach had been developed for the evaluation of the functional status of the thyroid gland, i.e. thyroid's secretory capacity (gain of thyroid, GT or SPINA-GT) and sum activity of peripheral deiodinases (GD or SPINA-GD). A second version has been established for insulin-glucose homeostasis. It delivers the secretory capacity of pancreatic beta cells (SPINA-GBeta), an estimate for the insulin receptor amplification (SPINA-GR) and a static disposition index as a measure for the loop gain of the feedback loop (SPINA-DI). Both implementations of SPINA have been validated in more than 50 clinical studies based on large cohorts.
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    Downloads: 8 This Week
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  • 3
    RawGeno Version 2.0-1 is released! RawGeno is an R CRAN library automating the scoring of AFLP electropherograms. The library includes a graphical user interface to simplify its use. Note that the 2.0-1 version is delivered as a source (*.tar.gz for Linux and Mac users) and as a binary file (*.zip, for Windows users). The installation procedure differs slightly according to your system; but this should remain simple. Have a look at the readme file when you download your new copy from https://sourceforge.net/projects/rawgeno/files/rawgeno/RawGeno%202.0-1/ Make also sure to have a look at https://sourceforge.net/projects/rawgeno/files/ where you can find a detailed manual, demo datasets and many demo scripts.
    Downloads: 2 This Week
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  • 4
    Mass-Up

    Mass-Up

    MALDI-TOF data analysis tool

    Mass-Up is an Open-Source mass spectrometry utility for proteomics designed to support the preprocessing and analysis of MALDI-TOF mass spectrometry data. Mass-Up includes several tools and operations to load, preprocess and analyze MALDI-TOF data.
    Downloads: 7 This Week
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  • 5
    ESTIMATE (Estimation of STromal and Immune cells in MAlignant Tumors using Expression data) is a new approach to use gene expression signature to infer the fraction of stromal and immune cells in tumor tissues.
    Downloads: 4 This Week
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  • 6
    Copy Number Analysis for Targeted Resequencing (CONTRA) is a tool for copy number variation (CNV) detection for targeted resequencing data such as those from whole-exome capture data.
    Downloads: 3 This Week
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  • 7
    IAP.G2P

    IAP.G2P

    IAP - the Integrated Analysis Pipeline

    The Integrated Analysis Platform (IAP) has been designed and developed to support the analysis of large-scale image data sets of different camera systems. It aims in bridging different data domains and in integrating different approaches to data analysis and post-processing.
    Downloads: 3 This Week
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  • 8

    MoPAC

    The Modular Pipeline for the Analysis of CRISPR screens

    To facilitate the comparison of gene essentialities in two or more cell samples, we propose MoPAC (Modular Pipeline for Analysis of CRISPR screens), a Shiny-driven interactive tool for differential essentiality analysis in CRISPR/Cas9 screens. For installation and usage instructions please refer to the wiki page.
    Downloads: 2 This Week
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  • 9
    The igraph library

    The igraph library

    Library for creating and manipulating graphs

    This is a library for creating and manipulating graphs with focus on speedy operations for large, sparse graphs.
    Downloads: 2 This Week
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  • 10
    ANDES. This is a library and a set of applications that can be used to analyze the results of deep sequencing results. (See Li et al.: ANDES: Statistical tools for the ANalyses of DEep Sequencing. BMC Research Notes 2010 3:199.)
    Downloads: 1 This Week
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  • 11

    BD-Func

    Bidirectional Functional Enrichment of Gene Expression Data

    BD-Func is an algorithm to predict activation or inhibition of pathways based upon gene expression patterns. If you use BD-Func, please cite: Warden C, Kanaya N, Chen S, and Yuan Y-C. (2013) BD-Func: A Streamlined Algorithm for Predicting Activation and Inhibition of Pathways. peerJ, 1:e159
    Downloads: 1 This Week
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    An implementation of the Kernel-based Orthogonal Projections to Latent Structures (K-OPLS) method for MATLAB and R. The supplied functionality includes e.g. cross-validation, kernel parameter optimization, model diagnostics and plot tools.
    Downloads: 1 This Week
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  • 13
    MetaBoFlux
    Metaboflux is a generic approach for predicting flux distribution in metabolic networks under multiple and various constraints deducted from the experiments, to increase the biological relevance of the model.
    Downloads: 1 This Week
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  • 14
    PANDA

    PANDA

    A comprehensive and flexible quantification tool for proteomics data

    PANDA is a comprehensive and flexib tool for quantitative proteomics data analysis, which is developed based on our solid foundations in quantitative proteomics for years. Several novelties have been implemented in it. First, we implement the advantage algorithms of LFQuant (Proteomics 2012, 12, (23-24), 3475-84) and SILVER (Bioinformatics 2014, 30, (4), 586-7) into PANDA. Second, we consider the state-of-art concept of quantification reliability in this quantitative workflow. On the levels of spectra, peptides and proteins, PANDA works out a few quantitative filters and new scores for quantification confidence. Third, PANDA is designed for processing proteomics big data in parallel.
    Downloads: 1 This Week
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  • 15

    TeachingDemos

    Bioinformatics related demos and tutorials using the R programming lan

    Bioinformatics related demos and tutorials using the R programming language for large biological data. Licence: Creative Commons Attribution-NonCommercial 4.0 International License
    Downloads: 1 This Week
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  • 16
    A header file (cexcept.h) that provides Try/Throw/Catch macros similar to those available in C++ for error handling.
    Downloads: 1 This Week
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  • 17
    dataMAPPs

    dataMAPPs

    R based pipeline for MHC-associated peptide proteomics (MAPPs) data

    dataMAPPs allows routine and efficient processing of data from immunogenicity studies applying the MAPPs peptidomics technology to detect potential MHCI- or MHC-II epitopes as presented by dendritic cells (DC). It features quality control of the raw data, across-sample/across-donor normalization and visualization of results in a heatmap style (heatMAPPs). dataMAPPs' core is a generic R library that can be tailored to specific projects via dedicated control scripts which also allow reproducible recalculation of results. Consult README file for installation and usage instructions. Further documentation is supplied in PDF format. dataMAPPs is published under GPL license by a team of scientists working for Hoffmann-La Roche AG in Basel, Switzerland. The software is provided as is, to hopefully benefit other researchers. Related Publication in the Journal of Proteome Research: DOI: 10.1021/acs.jproteome.0c00309
    Downloads: 1 This Week
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  • 18

    runjags

    The 'runjags' R package and standalone JAGS extension module

    This package provides high-level interface utilities for MCMC models via Just Another Gibbs Sampler (JAGS), facilitating the use of parallel (or distributed) processors for multiple chains, automated control of convergence and sample length diagnostics, and evaluation of the performance of a model using drop-k validation or against simulated data. Template model specifications can be generated using a standard lme4-style formula interface to assist users less familiar with the BUGS syntax. A JAGS extension module provides additional distributions including the Pareto family of distributions, the DuMouchel prior and the half-Cauchy prior.
    Downloads: 1 This Week
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  • 19
    vipR is a program to screen for sequence variants (SNPs, deletions) in sequence data generated by high-throughput-sequencing platforms. Information on this and other projects can be found on: http://www.altmann.eu
    Downloads: 1 This Week
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  • 20
    ADTEx

    ADTEx

    Aberration detection in tumour exome

    Aberration Detection in Tumour Exome (ADTEx) is a tool for copy number variation (CNV) detection for whole-exome data from paired tumour/matched normal samples.
    Downloads: 0 This Week
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  • 21
    ALEXA-Seq is a method for using massively parallel paired-end transcriptome sequencing for 'alternative expression analysis'.
    Downloads: 0 This Week
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  • 22
    AUTOMATED GENOTYPE CALLING OF LUMINEX ASSAYS
    Downloads: 0 This Week
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  • 23
    AWclust is easy to use non-parametric population structure analysis software written for R with a GUI interface. Just point and click and you will be on your way to discovering the important cluster information in your SNP data sets.
    Downloads: 0 This Week
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  • 24
    Acanthocephalan Proboscis Profiler is a tool for detecting acanthocephalan morphotypes.
    Downloads: 0 This Week
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  • 25
    Tools to build molecular-docking activity prediction models by PLS regression with iterative training and pose-selection. Descriptors include (i) docking score(s), (ii) pharmacophore features, (iii) multi-feature descriptors learned by decision trees.
    Downloads: 0 This Week
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