I restarted my computer again and now NAPS2 is working. On Oct 28, 2026, at 19:51, Ben Olden-Cooligan ben-cyanfish@users.sourceforge.net wrote: NAPS2 uses the standard Mac way to connect to scanners (at least for this device), so if it's not working in Image Capture, it's expected it won't work with NAPS2. Pretty much all I can recommend is to try re-installing the driver from the Epson support page: https://epson.com/Support/Scanners/Perfection-Series/Epson-Perfection-3490-Photo/s/SPT_B11B177011?review-filter=macOS+27.x+%28Golden+Gate%29...
I downloaded and installed the driver from the link you sent but it still says: Error Failed to open a connection to the device.  On Oct 28, 2026, at 19:51, Ben Olden-Cooligan ben-cyanfish@users.sourceforge.net wrote: NAPS2 uses the standard Mac way to connect to scanners (at least for this device), so if it's not working in Image Capture, it's expected it won't work with NAPS2. Pretty much all I can recommend is to try re-installing the driver from the Epson support page: https://epson.com/Support/Scanners/Perfection-Series/Epson-Perfection-3490-Photo/s/SPT_B11B177011?review-filter=macOS+27.x+%28Golden+Gate%29...
NAPS2 on MacOS Sequoia only works sporatically