Microsoft Agent Framework
Microsoft Agent Framework is an open source SDK and runtime designed to help developers build, orchestrate, and deploy AI agents and multi-agent workflows using languages such as .NET and Python. It combines the simple agent abstractions of AutoGen with the enterprise-grade capabilities of Semantic Kernel, including session-based state management, type safety, middleware, telemetry, and broad model and embedding support, creating a unified platform for both experimentation and production use. It introduces graph-based workflows that give developers explicit control over how multiple agents interact, execute tasks, and coordinate complex processes, enabling structured orchestration across sequential, concurrent, or branching scenarios. It supports long-running and human-in-the-loop workflows through robust state management, allowing agents to maintain context, reason through multi-step problems, and operate continuously over time.
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OpenAI Agents SDK
The OpenAI Agents SDK enables you to build agentic AI apps in a lightweight, easy-to-use package with very few abstractions. It's a production-ready upgrade of our previous experimentation for agents, Swarm. The Agents SDK has a very small set of primitives, agents, which are LLMs equipped with instructions and tools; handoffs, which allow agents to delegate to other agents for specific tasks; and guardrails, which enable the inputs to agents to be validated. In combination with Python, these primitives are powerful enough to express complex relationships between tools and agents, and allow you to build real-world applications without a steep learning curve. In addition, the SDK comes with built-in tracing that lets you visualize and debug your agentic flows, evaluate them, and even fine-tune models for your application.
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Mastra
Mastra is an open-source TypeScript framework for building, deploying, and managing AI agents and intelligent applications. The platform provides tools for developing autonomous agents, orchestrating multistep workflows, managing persistent memory, and integrating large language models with external services. Its agent framework supports configurable instructions, tool calling, structured outputs, and connections to thousands of AI models through a unified model router. Developers can create durable workflows with conditional branches, retries, human approval steps, and the ability to pause and resume long-running tasks. Mastra also includes agent observability, performance evaluations, tracing, metrics, and debugging tools to help developers monitor and improve AI applications. The framework integrates with React, Next.js, Node.js, and other JavaScript environments, with options for standalone deployment, Mastra Cloud hosting, and enterprise infrastructure.
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Upsonic
Upsonic is an open source framework that simplifies AI agent development for business needs. It enables developers to build, manage, and deploy agents with integrated Model Context Protocol (MCP) tools across cloud and local environments. Upsonic reduces engineering effort by 60-70% with built-in reliability features and service client architecture. It offers a client-server architecture that isolates agent applications, keeping existing systems healthy and stateless. It provides more reliable agents, scalability, and a task-oriented structure needed for completing real-world cases. Upsonic supports autonomous agent characterization, allowing self-defined goals and backgrounds, and integrates computer-use capabilities for executing human-like tasks. With direct LLM call support, developers can access models without abstraction layers, completing agent tasks faster and more cost-effectively.
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