Compare the Top On-Premises ELN Software as of January 2026

What is On-Premises ELN Software?

Electronic lab notebook (ELN) software provides researchers with the tools to optimize data collection and storage, transcription processes, information placement, and analysis operations. Compare and read user reviews of the best On-Premises ELN software currently available using the table below. This list is updated regularly.

  • 1
    LabWare LIMS
    14,000 laboratories. 125 countries. 98% customer satisfaction! Improve your lab's productivity, throughput, efficiency, data integrity, and compliance with LabWare's suite of laboratory automation solutions. LabWare offers flexible deployment options. Laboratories who are eager to deploy within 30 days can choose the cost-optimized + fully validated SaaS LIMS that contains best practice workflows. Laboratories that need a fully customizable enterprise-level LIMS/ELN can choose between flexible cloud or self-hosted deployment options. LabWare users enjoy world class features such as: lot management, sample management, stability management, environmental monitoring, instrument interfacing, workflows and dashboards, inventory management, COAs, barcoding, and much more!
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  • 2
    SciSure

    SciSure

    SciSure

    SciSure is dedicated to transforming laboratories worldwide with innovative digital solutions. We offer a comprehensive Digital Lab Platform (DLP), which integrates the Electronic Lab Notebook (ELN), Laboratory Information Management Systems (LIMS), machine learning, and AI. Our platform is designed to seamlessly integrate with your lab’s equipment and software, offering flexibility, security, and exceptional efficiency. By centralizing and optimizing all your research and process development workflows in a compliant environment, we empower researchers to focus on making ground-breaking discoveries. Our team of lab digitalization specialists is here to support you throughout your digitalization journey. 

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  • 3
    Sapio Sciences

    Sapio Sciences

    Sapio Sciences

    Sapio Sciences delivers the Sapio Platform, an agentic AI lab informatics platform that makes life in the lab easier and more productive for scientists. The unified, configurable, low code and scalable environment brings together Sapio LIMS, the market’s most advanced and flexible LIMS for automating research, diagnostics and manufacturing, Sapio ELaiN, the third generation AI lab notebook and scientific co scientist, and Sapio Scientific Data Cloud, the scientific data unification solution with built in organization, search, charting, tools and AI. Biopharma R&D, biotech, CRO and clinical diagnostics organizations use Sapio to run complex workflows and keep samples, experiments and data connected in one place instead of juggling disconnected systems.
  • 4
    Xybion LIMS
    Xybion LIMS (formerly Labwise XD) is an all-inclusive LIMS, ELN, QMS, and DMS. Xybion LIMS drives lab workflows, instills consistency, improves data quality, and supports regulatory compliance with a complete laboratory management solution that connects with your operating systems with powerful laboratory information management and analytics. Xybion LIMS creates optimized workflows for the unique business needs of all regulated laboratories including research, diagnostics, quality control, stability studies, and more.
  • 5
    eLabNotes

    eLabNotes

    Dima Engineering

    eLabNotes™ – A Flexible and Powerful Electronic Lab Notebook eLabNotes™ is an electronic lab notebook (ELNB) that simplifies research workflows for scientists and teams. It offers tools for experiment recording, data management, and collaboration. Designed for scalability and customization, eLabNotes™ improves lab operations, data security, and research reproducibility. Key Features: * Synthesis module with templates, chemistry tools, and analytics integration. * Formulations module for dosage design, BOM setup, and audit trails. * Analytical module for sample management, automated results, and raw data attachment. * Stability management for protocol definition, scheduling, and reminders. * Inventory tracking for materials, equipment, and consumables. * Project monitoring for timelines, budgets, and milestones. * Custom dashboards tailored to roles like scientists and analysts. Get started with eLabNotes™ today and take your research to the next level!
  • 6
    LabVantage

    LabVantage

    LabVantage

    Productive, efficient labs operate on the LabVantage platform – a combination of laboratory information management system (LIMS), electronic lab notebook (ELN), lab execution system (LES), and scientific data management system (SDMS). Intelligently deployed via zero-footprint web browser-based user interface, LabVantage is available for enterprises of all sizes, as pre-packaged solutions for specific industries, and via on-premise, cloud-hosted, or SaaS implementations. Our solutions help lab managers, scientists, and technicians better manage everything: from instruments and materials to experiments and reports to regulatory compliance and data integrity. A recognized leader in enterprise laboratory software solutions, LabVantage Solutions dedicates itself to improving customer outcomes by transforming data into knowledge.
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