PyGPT is an open source, personal desktop AI assistant for Linux, Windows, and Mac, written in Python. It works similarly to ChatGPT, but locally on a desktop computer, with chat, vision, agents, image and video generation, tools, voice control, and more. PyGPT supports multiple models, including OpenAI GPT-5, GPT-4, o1, o3, o4, Google Gemini, Anthropic Claude, xAI Grok, Perplexity Sonar, DeepSeek, Mistral AI, and models accessible through Ollama and LlamaIndex. It offers 12 modes of operation, including chat, chat with files, realtime + audio, research, completion, image and video generation, vision, assistants, experts, computer use, agents, and autonomous mode. Users can chat with their own files and data using integrated LlamaIndex support. PyGPT includes built-in vector database support, automated files and data embedding, full conversation context, short- and long-term memory, internet access through Google, Microsoft Bing, and DuckDuckGo, plus speech synthesis and recognition.