Best AI Agent Frameworks for Python
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Compare the Top AI Agent Frameworks that integrate with Python as of May 2026
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This a list of AI Agent Frameworks that integrate with Python. Use the filters on the left to add additional filters for products that have integrations with Python. View the products that work with Python in the table below.
What are AI Agent Frameworks for Python?
AI agent frameworks are software development platforms, SDKs, and libraries designed to build, orchestrate, and manage autonomous or semi-autonomous artificial intelligence agents. They provide foundational components such as reasoning engines, memory systems, action planning, tool integrations, and lifecycle control so developers can create intelligent agents without building every capability from scratch. These frameworks often include standardized interfaces, debugging tools, simulation environments, and performance monitoring to support robust agent development and deployment. Many AI agent frameworks integrate with existing machine learning models, APIs, and external systems to enable agents to interact with real-world data and services. By abstracting complex agent behaviors into reusable patterns and tools, AI agent frameworks accelerate innovation and help teams deploy reliable, scalable intelligent systems. Compare and read user reviews of the best AI Agent Frameworks for Python currently available using the table below. This list is updated regularly.
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1
LangChain
LangChain
LangChain is a powerful, composable framework designed for building, running, and managing applications powered by large language models (LLMs). It offers an array of tools for creating context-aware, reasoning applications, allowing businesses to leverage their own data and APIs to enhance functionality. LangChain’s suite includes LangGraph for orchestrating agent-driven workflows, and LangSmith for agent observability and performance management. Whether you're building prototypes or scaling full applications, LangChain offers the flexibility and tools needed to optimize the LLM lifecycle, with seamless integrations and fault-tolerant scalability. -
2
LangGraph
LangChain
Gain precision and control with LangGraph to build agents that reliably handle complex tasks. Build and scale agentic applications with LangGraph Platform. LangGraph's flexible framework supports diverse control flows – single agent, multi-agent, hierarchical, sequential – and robustly handles realistic, complex scenarios. Ensure reliability with easy-to-add moderation and quality loops that prevent agents from veering off course. Use LangGraph Platform to templatize your cognitive architecture so that tools, prompts, and models are easily configurable with LangGraph Platform Assistants. With built-in statefulness, LangGraph agents seamlessly collaborate with humans by writing drafts for review and awaiting approval before acting. Easily inspect the agent’s actions and "time-travel" to roll back and take a different action to correct course.Starting Price: Free -
3
Riff
Riff
Riff is an AI agent platform designed to automate complex business workflows across enterprise systems. It enables organizations to build and deploy AI agents that handle tasks like reconciliation, exception management, and decision-making. The platform integrates directly with tools such as ERP systems, Salesforce, ServiceNow, and data platforms. Riff allows businesses to move from manual processes to automated workflows in just a few weeks. It empowers domain experts within teams to build and manage AI agents without heavy engineering dependencies. The platform ensures enterprise-grade governance, security, and compliance from the start. Overall, Riff helps organizations improve efficiency and drive measurable business outcomes through AI automation.Starting Price: $49 per month -
4
Semantic Kernel
Microsoft
Semantic Kernel is a lightweight, open-source development kit that lets you easily build AI agents and integrate the latest AI models into your C#, Python, or Java codebase. It serves as an efficient middleware that enables rapid delivery of enterprise-grade solutions. Microsoft and other Fortune 500 companies are already leveraging Semantic Kernel because it’s flexible, modular, and observable. Backed with security-enhancing capabilities like telemetry support, hooks, and filters you’ll feel confident you’re delivering responsible AI solutions at scale. Version 1.0+ support across C#, Python, and Java means it’s reliable, and committed to nonbreaking changes. Any existing chat-based APIs are easily expanded to support additional modalities like voice and video. Semantic Kernel was designed to be future-proof, easily connecting your code to the latest AI models evolving with the technology as it advances.Starting Price: Free -
5
PydanticAI
Pydantic
PydanticAI is a Python-based agent framework designed to simplify the development of production-grade applications using generative AI. Built by the team behind Pydantic, the framework integrates seamlessly with popular AI models such as OpenAI, Anthropic, Gemini, and others. It offers type-safe design, real-time debugging, and performance monitoring through Pydantic Logfire. PydanticAI also provides structured responses by leveraging Pydantic to validate model outputs, ensuring consistency. The framework includes a dependency injection system to support iterative development and testing, as well as the ability to stream LLM outputs for rapid validation. It is ideal for AI-driven projects that require flexible and efficient agent composition using standard Python best practices. We built PydanticAI with one simple aim: to bring that FastAPI feeling to GenAI app development.Starting Price: Free -
6
Agno
Agno
Agno is a lightweight framework for building agents with memory, knowledge, tools, and reasoning. Developers use Agno to build reasoning agents, multimodal agents, teams of agents, and agentic workflows. Agno also provides a beautiful UI to chat with agents and tools to monitor and evaluate their performance. It is model-agnostic, providing a unified interface to over 23 model providers, with no lock-in. Agents instantiate in approximately 2μs on average (10,000x faster than LangGraph) and use about 3.75KiB memory on average (50x less than LangGraph). Agno supports reasoning as a first-class citizen, allowing agents to "think" and "analyze" using reasoning models, ReasoningTools, or a custom CoT+Tool-use approach. Agents are natively multimodal and capable of processing text, image, audio, and video inputs and outputs. The framework offers an advanced multi-agent architecture with three modes, route, collaborate, and coordinate.Starting Price: Free -
7
Swarm
OpenAI
Swarm is an experimental, educational framework developed by OpenAI to explore ergonomic, lightweight multi-agent orchestration. It is designed to be scalable and highly customizable, making it suitable for scenarios involving a large number of independent capabilities and instructions that are challenging to encode into a single prompt. Swarm operates entirely on the client side and, like the Chat Completions API it utilizes, does not store state between calls. This stateless nature allows for the construction of scalable, real-world solutions without a steep learning curve. Swarm agents are distinct from assistants in the assistants API; they are named similarly for convenience but are otherwise completely unrelated. It includes examples demonstrating fundamentals such as setup, function calling, handoffs, and context variables, as well as more complex scenarios like a multi-agent setup for handling different customer service requests in an airline context.Starting Price: Free -
8
OpenAI Agents SDK
OpenAI
The OpenAI Agents SDK enables you to build agentic AI apps in a lightweight, easy-to-use package with very few abstractions. It's a production-ready upgrade of our previous experimentation for agents, Swarm. The Agents SDK has a very small set of primitives, agents, which are LLMs equipped with instructions and tools; handoffs, which allow agents to delegate to other agents for specific tasks; and guardrails, which enable the inputs to agents to be validated. In combination with Python, these primitives are powerful enough to express complex relationships between tools and agents, and allow you to build real-world applications without a steep learning curve. In addition, the SDK comes with built-in tracing that lets you visualize and debug your agentic flows, evaluate them, and even fine-tune models for your application.Starting Price: Free -
9
Cua
Cua
Cua is a computer-use agent platform that lets AI agents see screens, click buttons, type, and run code just like a human across macOS, Windows, Linux, browsers, and mobile environments. It provides cloud-based, sandboxed desktops where agents can automate real software workflows without relying on APIs. Built on open-source Cua agents, the platform enables developers to build, run, and scale computer-use agents with precision and reliability. Cua supports multi-step tasks, structured outputs, and human-in-the-loop recovery for complex automation. Agents operate in fully isolated environments to ensure safety and reproducibility. Cua is designed to make AI interaction with real applications practical and scalable.Starting Price: $10/month -
10
AgentSea
AgentSea
AgentSea is an open source platform designed to build, deploy, and share AI agents with ease. It delivers a collection of libraries and tools for building AI agent apps, favoring the UNIX philosophy of doing one thing well. Tools can be used individually or stacked together into a single agent app, and are compatible with frameworks like LlamaIndex and LangChain. Key components include SurfKit, a Kubernetes-style orchestrator for agents; DeviceBay, offering pluggable devices like file systems and desktops; ToolFuse, a library that wraps scripts, third-party apps, and APIs as Tool implementations; AgentD, a daemon making a Linux desktop OS accessible to bots; AgentDesk, a library for running AgentD-powered VMs; Taskara, for task management; ThreadMem, for building multi-role persistent threads; and MLLM, simplifying communication with multiple LLMs and multimodal LLMs. AgentSea also offers alpha agents like SurfPizza and SurfSlicer, which navigate GUIs using multimodal approaches.Starting Price: Free -
11
Agent Squad
Amazon
Agent Squad is a flexible and powerful open source framework developed by AWS for managing multiple AI agents and handling complex conversations. It enables multi-agent orchestration, allowing seamless coordination and leveraging of multiple AI agents within a single system. It offers dual language support, being fully implemented in both Python and TypeScript. Intelligent intent classification dynamically routes queries to the most suitable agent based on context and content. Agent Squad supports both streaming and non-streaming responses from different agents, ensuring flexible agent responses. It maintains and utilizes conversation context across multiple agents for coherent interactions. The architecture is extensible, allowing easy integration of new agents or customization of existing ones to fit specific needs. Agent Squad can be deployed universally, running anywhere from AWS Lambda to local environments or any cloud platform.Starting Price: Free -
12
Strands Agents
Strands Agents
Strands Agents is an open-source framework designed to help developers build controllable and flexible AI agents using Python and TypeScript. It enables users to create agents by defining tools as simple functions, eliminating the need for complex workflows or orchestration pipelines. The SDK works with any model and cloud provider, giving developers full freedom in how they deploy and scale their agents. It introduces a streamlined agent loop where the model handles reasoning while developers maintain control through code. Features like steering hooks allow developers to validate and guide agent behavior before and after actions are taken. The platform also includes built-in capabilities such as memory management, observability, and evaluation tools. Overall, Strands Agents SDK simplifies agent development while improving reliability, control, and performance.Starting Price: Free -
13
TEN
TEN
TEN (Transformative Extensions Network) is an open source framework designed to empower developers to build real-time multimodal AI agents capable of voice, video, text, image, and data-stream interaction with ultra-low latency. It includes a full ecosystem, TEN Turn Detection, TEN Agent, and TMAN Designer, allowing developers to rapidly assemble human-like, responsive agents that can see, speak, hear, and interact. With support for languages like Python, C++, and Go, it offers flexible deployment on both edge and cloud environments. Using components like graph-based workflow design, drag-and-drop UI (via TMAN Designer), and reusable extensions such as real-time avatars, RAG (Retrieval-Augmented Generation), and image generation, TEN enables highly customizable, scalable agent development with minimal code.Starting Price: Free -
14
AgentKit
OpenAI
AgentKit is a unified suite of tools designed to streamline the process of building, deploying, and optimizing AI agents. It introduces Agent Builder, a visual canvas that lets developers compose multi-agent workflows via drag-and-drop nodes, set guardrails, preview runs, and version workflows. The Connector Registry centralizes the management of data and tool integrations across workspaces and ensures governance and access control. ChatKit enables frictionless embedding of agentic chat interfaces, customizable to match branding and experience, into web or app environments. To support robust performance and reliability, AgentKit enhances its evaluation infrastructure with datasets, trace grading, automated prompt optimization, and support for third-party models. It also supports reinforcement fine-tuning to push agent capabilities further.Starting Price: Free -
15
Claude Agent SDK
Claude
The Claude Agent SDK is a developer toolkit that enables the creation of autonomous AI agents powered by Claude, allowing them to perform real-world tasks beyond simple text generation by interacting directly with files, systems, and tools. It provides the same underlying infrastructure used by Claude Code, including an agent loop, context management, and built-in tool execution, and is available for use in Python and TypeScript. With this SDK, developers can build agents that read and write files, execute shell commands, search the web, edit code, and automate complex workflows without needing to implement these capabilities from scratch. It maintains persistent context and state across interactions, enabling agents to operate continuously, reason through multi-step problems, take actions, verify results, and iterate until tasks are completed.Starting Price: Free -
16
Microsoft Agent Framework
Microsoft
Microsoft Agent Framework is an open source SDK and runtime designed to help developers build, orchestrate, and deploy AI agents and multi-agent workflows using languages such as .NET and Python. It combines the simple agent abstractions of AutoGen with the enterprise-grade capabilities of Semantic Kernel, including session-based state management, type safety, middleware, telemetry, and broad model and embedding support, creating a unified platform for both experimentation and production use. It introduces graph-based workflows that give developers explicit control over how multiple agents interact, execute tasks, and coordinate complex processes, enabling structured orchestration across sequential, concurrent, or branching scenarios. It supports long-running and human-in-the-loop workflows through robust state management, allowing agents to maintain context, reason through multi-step problems, and operate continuously over time.Starting Price: Free -
17
Smolagents
Smolagents
Smolagents is an AI agent framework developed to simplify the creation and deployment of intelligent agents with minimal code. It supports code-first agents where agents execute Python code snippets to perform tasks, offering enhanced efficiency compared to traditional JSON-based approaches. Smolagents integrates with large language models like those from Hugging Face, OpenAI, and others, enabling developers to create agents that can control workflows, call functions, and interact with external systems. The framework is designed to be user-friendly, requiring only a few lines of code to define and execute agents. It features secure execution environments, such as sandboxed spaces, for safe code running. Smolagents also promotes collaboration by integrating deeply with the Hugging Face Hub, allowing users to share and import tools. It supports a variety of use cases, from simple tasks to multi-agent workflows, offering flexibility and performance improvements. -
18
TF-Agents
Tensorflow
TensorFlow Agents (TF-Agents) is a comprehensive library designed for reinforcement learning in TensorFlow. It simplifies the design, implementation, and testing of new RL algorithms by providing well-tested modular components that can be modified and extended. TF-Agents enables fast code iteration with good test integration and benchmarking. It includes a variety of agents such as DQN, PPO, REINFORCE, SAC, and TD3, each with their respective networks and policies. It also offers tools for building custom environments, policies, and networks, facilitating the creation of complex RL pipelines. TF-Agents supports both Python and TensorFlow environments, allowing for flexibility in development and deployment. It is compatible with TensorFlow 2.x and provides tutorials and guides to help users get started with training agents on standard environments like CartPole. -
19
Upsonic
Upsonic
Upsonic is an open source framework that simplifies AI agent development for business needs. It enables developers to build, manage, and deploy agents with integrated Model Context Protocol (MCP) tools across cloud and local environments. Upsonic reduces engineering effort by 60-70% with built-in reliability features and service client architecture. It offers a client-server architecture that isolates agent applications, keeping existing systems healthy and stateless. It provides more reliable agents, scalability, and a task-oriented structure needed for completing real-world cases. Upsonic supports autonomous agent characterization, allowing self-defined goals and backgrounds, and integrates computer-use capabilities for executing human-like tasks. With direct LLM call support, developers can access models without abstraction layers, completing agent tasks faster and more cost-effectively. -
20
GraphBit
GraphBit
GraphBit is an enterprise-grade agentic AI framework built to run critical AI systems with security, governance, and predictable production performance. It combines a Rust execution core with a Python wrapper to give developers high-performance orchestration with the accessibility of Python, helping teams build reliable multi-agent workflows with minimal CPU and memory usage. GraphBit is designed around the layers that reduce risk, including interfaces, configuration, models, tools, actions, memory, orchestration, and observability. It integrates into existing apps, powers custom AI interfaces, and lets users interact through familiar workflows with controlled actions. Teams can define policies, rules, and guardrails centrally, while GraphBit enforces behavior without changing application code. It supports LLMs and multimodal models from multiple providers, allowing teams to swap models freely without breaking workflows or governance.
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