Venster is a highly native Windows GUI toolkit for Python based on the
ctypes ffi library. The aim of Venster is to be a very lightweight wrapper around the standard Win32 API, making it easy to write slick windows applications in pure Python.
Fantastic Python ctypes module my small version http://pywingui.googlecode.com
Very good and useful project, see continue here http://code.google.com/p/venster-continue/