Stochastic simulation model of poliovirus Sabin-to-Mahoney genetic state transition (C++ code). Models genotypes, virus populations, and quasispecies cloud. Simulates replication error and copy-choice recombination. Various parameters guiding the model are user-specified. Python code post-processes simulation output to produce report files.

Features

  • Simulates Picornavirus replication error and copy-choice recombination
  • Represents genotypes, cell populations, and quasispecies cloud
  • Allows user control of parameters: MOI, replication error rate, recombination rate, generational growth rate, burst size, number of passages, number of cells, fitness acceleration, Mahoney mutational synergy
  • Reports population diversity, average fitness, neurovirulence, Mahoney resemblence

Project Activity

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Categories

Bio-Informatics

License

GNU General Public License version 3.0 (GPLv3)

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Additional Project Details

Intended Audience

Science/Research, Education, Advanced End Users, Developers

Programming Language

Python, C++

Related Categories

Python Bio-Informatics Software, C++ Bio-Informatics Software

Registered

2016-02-19
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