Virus QSP Modeling download

Stochastic simulation model of poliovirus Sabin-to-Mahoney genetic state transition (C++ code). Models genotypes, virus populations, and quasispecies cloud. Simulates replication error and copy-choice recombination. Various parameters guiding the model are user-specified. Python code post-processes simulation output to produce report files.

Features

Simulates Picornavirus replication error and copy-choice recombination
Represents genotypes, cell populations, and quasispecies cloud
Allows user control of parameters: MOI, replication error rate, recombination rate, generational growth rate, burst size, number of passages, number of cells, fitness acceleration, Mahoney mutational synergy
Reports population diversity, average fitness, neurovirulence, Mahoney resemblence

Project Activity

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License

GNU General Public License version 3.0 (GPLv3)

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Additional Project Details

Intended Audience

Advanced End Users, Developers, Education, Science/Research

Programming Language

C++, Python

Related Categories

Python Bio-Informatics Software, C++ Bio-Informatics Software

Registered

2016-02-19

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