Pydub

Manipulate audio with a simple and easy high level interface. You can pass an optional bitrate argument to export using any syntax ffmpeg supports. Any further arguments supported by ffmpeg can be passed as a list in a 'parameters' argument, with switch first, argument second. Note that no validation takes place on these parameters, and you may be limited by what your particular build of ffmpeg/avlib supports. You can open and save WAV files with pure python. For opening and saving non-wav files, like mp3, you'll need ffmpeg or libav. Any operations that combine multiple AudioSegment objects in any way will first ensure that they have the same number of channels, frame rate, sample rate, bit depth, etc.