PoreMeth

PoreMeth is a tool for the detection of differentially methylated regions (DMRs) from nanopore sequencing data of two samples. PoreMeth tool is based on a heterogeneous form of the shifting level model, which integrates distances between consecutive CpGs in the segmentation algorithm. PoreMeth is fed with ∆β values and generates genomic segments with increased (hyper-) or decreased (hypo-) methylation levels between two samples, which are then evaluated for statistical significance using the Wilcoxon-rank sum test.