MoPAC

To facilitate the comparison of gene essentialities in two or more cell samples, we propose MoPAC (Modular Pipeline for Analysis of CRISPR screens), a Shiny-driven interactive tool for differential essentiality analysis in CRISPR/Cas9 screens.

For installation and usage instructions please refer to the wiki page.

Features

Unbiased measurement of differential gene essentiality in CRISPR screens.
Ease of use through an interactive graphical user interphase.
Publication-ready figures generated at every step of the analysis.
Both FASTQ files and read-count tables (before or after normalization) allowed as input.
Gene-category-based quality control for outlier detection and filtering.
Gene ontology analysis built-in through the STRINGdb R package.
Fast processing through C++ compilation of calculation-intensive steps.

Project Samples

Condition quality control and annotation

Log-fold-change visualization, correlation, clustering, PCA and reproducibility at both the sgRNA and gene levels

Gene essentiality and training-set filtering

Differential essentiality, interaction network and GO enrichment

Project Activity

See All Activity >

License

GNU General Public License version 3.0 (GPLv3)

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MoPAC Web Site

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Additional Project Details

Intended Audience

Science/Research

User Interface

Web-based

Programming Language

C++, S/R

Related Categories

C++ Bio-Informatics Software, S/R Bio-Informatics Software

Registered

2018-07-20

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