If you want to create a Flash or WebGL powered game in C# JSC is what you need. If you want to create a single page web application JSC is what you need!
JSC also integrates with NuGet which allows to create packages.
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This is the best solution I have discovered ever. please be updated and provide us with newer things.
This is what i've been searching for about 3 years, but somehow Google avoids it. It's absolutely gorgeous.