EpiTopoFold

Here, we developed a topology-driven scaffold design model, EpiTopoFold, that systematically explores protein secondary-structure arrangements to identify optimal scaffolds for discontinuous epitope segments.
Citation: Ma, Y.F., Yin, G.H., Pan, Y., and Liu, Y. (2026). Intelligent antigen design combined with yeast display enhances targeted immune responses. Briefings in Bioinformatics 27, bbag393.