6. DHOEM (Windows)

DHOEM (Densification of Haplotypes by lOEess and Maximum Likelihood) is a novel R application which performs simulation of new markers in real SNP marker data. The new markers are generated according to real local data characteristics, modeled statistically, and are interpolated locally between real markers in the data. The function allows the user to specify a desired level of marker density, with a minor allele frequency (MAF) limit, which is produced in a reasonable computation time. Reference: http://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-015-0830-7