I installed TiLP according to the Readme file on my Mac with OS X 10.6.3. It started fine, but wouldn't recognize that my TI-89 Titanium was plugged in with the black USB cable I got with the calculator. After I was searching around the preferences, I tried switching the cable types used to see if that would fix the problem. It didn't so I quit the program, and attempted to restart, but it will not open now. I would try to uninstall, but I cannot find directions to uninstall the program properly.
I know this isn't Windows, but try rebooting the computer nevertheless. I've already seen a hung libticables prevent TILP from starting properly.
Already tried it, unfortunately it didn't help any. Any other ideas?