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#366 Suggested change to SBML multi-compartment model example

Reported-Proposed
closed
nobody
5
2022-07-13
2020-03-31
No

We should update the example of multicompartmental model use in the SBML specification (example 7.8 on p. 130 of SBML Level 3 Version 2 Core Release 2 of 29 March 2019 as the current definition is problematic, being both ambiguous and incorrectly scaled.

Submitted on behalf of Prof J.-H.S. Hofmeyr who suggests the following:

"""
I suggest the following changes to the SBML compartment model so that it can serve as an example of correct scaling. Replace

v_T = k_T (y_1n - y_1c) V_c

with

v_T = k_T (y_1n - y_1c) A

and provide new values for A (in dm^2) and k_T (in dm/s) that still give A.k_T = 25000 dm^3/s (the value that V_c.k_T currently gives). In fact, just make A = 1 dm^2. This means that the model will still give identical numerical output.

This also means that they can just write "The reaction between the compartments called cytosol and nucleus is a transport reaction whose detailed mechanism is not modeled here; it is regarded simply as a reversible process that spans the two three-dimensional compartments."
"""

Discussion

  • Frank Bergmann

    Frank Bergmann - 2020-03-31

    I agree with this suggestion.

     
  • Michael Hucka

    Michael Hucka - 2020-03-31

    Nice catch by Dr. Hofmeyr. Thank you for bringing this up.

     
  • Lucian Smith

    Lucian Smith - 2020-04-22
    • labels: --> Level 2 Version 5 Core, Level 3 Version 1 Core, Level 3 Version 2 Core
     
  • Lucian Smith

    Lucian Smith - 2022-07-13
    • status: open --> closed
     

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