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From: Melanie C. <mco...@gm...> - 2009-04-06 19:38:15
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Hi Jennifer, Sorry I couldn't make it this morning (next Monday is a holiday here as well) On 6-Apr-09, at 9:20 AM, Fostel, Jennifer (NIH/NIEHS) [C] wrote: > Oliver and I met today > we added host role: pathogen role is a role which inheres in an > organislm and realized in the process of disease course in the > organism bearing host role caused by the organism bearing pathogen > role So you are thinking having a pathogen disposition (e.g. for the ebola virus in a tube somewhere in a fridge) and a pathogen role which is realized when the ebola virus infects an organism. I have a few questions: - isn't a pathogen always pathogen for a specific organism? E.g. the Cowpox virus is pathogen only for cows. So the pathogenic disposition would be some kind of relational disposition between a pathogen and an organism? - if I am infected by a pathogen, and it doesn't cause the disease (because I am immune, vaccinated or else), it wouldn't realize its pathogen role, right? - should the pathogen role/disposition be restricted to more than just organism as bearers? I don't think a human can be a pathogen. Maybe virus, bacteria, fungi? > > we are working on virulence factor and toxin > we would like to meet with the disposition branch for dispositions > such as toxin, pathogen, host, host-range, virulence factor, > allergen, immune response, disease. There is no real disposition branch. Several people have been taking care of it when additions were needed. Lately I think it was mostly Alan and I. Maybe if we can work on definitions as a starting point? > > we also need to discuss with PPA branch as to how to represent > objective of causing disease course and immune / allergic response > > at our next call we will add an agent role / disposition; examples > of agent = an active and efficient cause; capable of producing a > certain effect; One that acts or has the power or authority to act > cfwww.answers.com/topic/intelligent-agents ; wordnet.princeton.edu/ > perl/webwn Could you give me more details on the use case for that one? Thanks, Melanie > > ...jennifer > > > Jennifer Fostel, Ph.D. > CEBS Scientific Administrator > Global Health Sector, SRA International, Inc > > Laboratory of Respiratory Biology > NIEHS, NIH > PO Box 12233 Mail Drop F1-05 > 111 Alexander Drive > Research Triangle Park NC 27709-2233 > > phone 919 541 5055 > fax 919 541 1460 > > > ------------------------------------------------------------------------------ > _______________________________________________ > Obi-role-branch mailing list > Obi...@li... > https://lists.sourceforge.net/lists/listinfo/obi-role-branch --- Mélanie Courtot TFL- BCCRC 675 West 10th Avenue Vancouver, BC V5Z 1L3, Canada |