Re: [Obi-role-branch] role branch notes april 6

[Melanie C. <mco...@gm...>]

Hi Jennifer,

Sorry I couldn't make it this morning (next Monday is a holiday here  
as well)

On 6-Apr-09, at 9:20 AM, Fostel, Jennifer (NIH/NIEHS) [C] wrote:

> Oliver and I met today
> we added host role:  pathogen role is a role which inheres in an  
> organislm and realized in the process of disease course in the  
> organism bearing host role caused by the organism bearing pathogen  
> role

So you are thinking having a pathogen disposition (e.g. for the ebola  
virus in a tube somewhere in a fridge) and a pathogen role which is  
realized when the ebola virus infects an organism.

I have a few questions:
- isn't a pathogen always pathogen for a specific organism? E.g. the  
Cowpox virus is pathogen only for cows. So the pathogenic disposition  
would be some kind of relational disposition between a pathogen and an  
organism?
- if I am infected by a pathogen, and it doesn't cause the disease  
(because I am immune, vaccinated or else), it wouldn't realize its  
pathogen role, right?
- should the pathogen role/disposition be restricted to more than just  
organism as bearers? I don't think a human can be a pathogen. Maybe  
virus, bacteria, fungi?

>
> we are working on virulence factor and toxin
> we would like to meet with the disposition branch for dispositions  
> such as toxin, pathogen, host, host-range, virulence factor,  
> allergen, immune response, disease.

There is no real disposition branch. Several people have been taking  
care of it when additions were needed. Lately I think it was mostly  
Alan and I.
Maybe if we can work on definitions as a starting point?


>
> we also need to discuss with PPA branch as to how to represent  
> objective of causing disease course and immune / allergic response
>
> at our next call we will add an agent role / disposition; examples  
> of agent = an active and efficient cause; capable of producing a  
> certain effect; One that acts or has the power or authority to act  
> cfwww.answers.com/topic/intelligent-agents ; wordnet.princeton.edu/ 
> perl/webwn

Could you give me more details on the use case for that one?

Thanks,
Melanie


>
> ...jennifer
>
>
> Jennifer Fostel, Ph.D.
> CEBS Scientific Administrator
> Global Health Sector, SRA International, Inc
>
> Laboratory of Respiratory Biology
> NIEHS, NIH
> PO Box 12233 Mail Drop F1-05
> 111 Alexander Drive
> Research Triangle Park NC 27709-2233
>
> phone 919 541 5055
> fax 919 541 1460
>
>
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---
Mélanie Courtot
TFL- BCCRC
675 West 10th Avenue
Vancouver, BC
V5Z 1L3, Canada