Search Results for "multiple sequence alignment" - Page 7
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Showing 231 open source projects for "multiple sequence alignment"
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Editor.md
The open source embeddable online markdown editor (component)
The open source embeddable online markdown editor (component), based on CodeMirror & jQuery & Marked. The available dependents are CodeMirror, marked, jQuery, FontAwesome, github-markdown.css, KaTeX, prettify.js, Rephael.js, flowchart.js, sequence-diagram.js, and Prefixes.scss. You can enable HTML tags decode, TeX, Flowchart, sequence diagram, Emoji, FontAwesome, task lists. You can also enable image upload, [TOCM], search replace features, code fold, etc. Combine multiple JS module files used by CodeMirror to greatly reduce HTTP requests and speed up downloading. In addition, when using Require.js, because of CodeMirror's strict module dependency restrictions, the merged module files cannot be used, and multiple module files are still dynamically loaded. ... -
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GenoSuite is a framework developed for proteogenomic analysis. An updated GenoSuite2 is just released where FDRScore (Jones et al. Proteomics 2009) based strategy is used to integrate results from multiple search algorithms. Prokaryotic Proteogenomic Tool(PPT) is developed as a part of GenoSuite framework. PPT is for finding novel translations in prokaryotic genomes and is dependent on Mass Spectrometry based proteomics data and related genome sequence. Some Key features of the tool are.... (1) Configured for 4 open source algorithms to perform database searching for peptide identification. ...
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GenomeView is a genome browser and annotation editor that displays reference sequence, annotation, multiple alignments, short read alignments and graphs. Most major data formats are supported. Local and internet files can be loaded. This project has moved to GitHub: https://github.com/GenomeView/genomeview
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GESPA
Accurately predicts disease association of single nucleotide mutations
...Using reports from literature, GESPA is also able to predict the phenotype of a nsSNP with high accuracy. The software can be used clinically to determine if observed nsSNPs are associated with disease. A host of annotations are provided: orthologous and paralogous multiple sequence alignments, UCSC annotations, reports detailing conservation of a nsSNP in alignments, and links to external nsSNP and gene information such as relevant publications. GESPA is connected to a constantly updating SQL server allowing for fast data retrieval. NOTE: REQUIRES Java 1.7.0+. Port 1433 cannot be blocked by firewall, network, or antivirus program. ... -
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chipexo
model based analysis of ChIP-exo data
...When applied to yeast Reb1 and human CTCF ChIP-exo data, MACE is able to define TFBSs with higher sensitivity, specificity and spatial resolution, as evidenced by multiple criteria, such as motif enrichment, sequence conservation, nucleosome positioning, and open chromatin states. -
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StatAlign
An extendable statistical multiple alignment tool.
StatAlign is an extendable software package for Bayesian analysis of Protein, DNA and RNA sequences. Multiple alignments, phylogenetic trees and evolutionary parameters are co-estimated in a Markov Chain Monte Carlo framework, allowing for reliable measurement of the accuracy of the results. This approach eliminates common artifacts that traditional methods suffer from, at the cost of increased computational time. These artifacts include the dependency of the constructed phylogeny on a single (probably suboptimal) alignment and bias towards the guide tree upon which the alignment relies. ... -
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ALTER is a web-based tool to transform between multiple sequence alignment formats. ALTER focuses on the specifications of mainstream alignment and analysis programs rather than on the conversion among more or less specific formats.
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EnsembleAssembly
Ensemble de novo sequence assembly of metagenomic data
EnsembleAssembler performs de novo assembly of pathogen genomes from metagenomic samples sequenced using Illumina platforms. EnsembleAssembler optimizes contig formation by integrating results from multiple assemblers including SOAPDenovo2, ABySS, MetaVelvet, and Cap3. The software does NOT perform preprocessing. The user needs to do preprocessing with other software before attempting for assembly. -
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DNATweezer
A suite of BioPerl wrappers for manipulating DNA and protein sequences
...These scripts provide command-line access to the most frequently used BioPerl DNA object methods e.g. reverse-complement and translation of DNA sequences, slicing a sequence alignment, rerooting a phylogenetic tree, and calculating diversity of a population of DNA sequences. -
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dna-bison
Bisulfite alignment On Nodes of a cluster
Bison allows users with access to a computer cluster to rapidly align whole-genome bisulfite sequencing or RRBS reads. It can align both directional and non-directional libraries and uses bowtie2. Multiple compute nodes are not absolutely required, but will make the alignment process faster. Further details available on the Wiki page. Help also available on SEQanswers (http://seqanswers.com/forums/showthread.php?t=31314) or by creating a ticket here. You can now track the development on github (https://github.com/dpryan79/bison). ... -
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NOTE: developement of this project has moved to GitHub http://github.org/matthuska/biasviz/ BiasViz is a Java applet for visualization of amino acid bias in multiple sequence alignments.
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MARAGAP
MARAGAP - Modular Approach to Reference Assisted Genome Assembly Pi...
This paper presents `MARAGAP', a reference assisted genome assembly pipeline. MARAGAP uses the principle of Minimum Description Length to determine the optimal reference sequence for the assembly. The optimal reference sequence is used as a template to infer inversions, insertions, deletions and SNPs in the target genome. MARAGAP uses an algorithmic approach to detect and correct inversions and deletions, a De-Bruijn graph based approach to infer the insertions, an affine-match affine-gap local alignment tool to estimate the locations of those insertions and a Bayesian estimation framework for SNPs. -
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GLProbs
GLProbs: Aligning multiple sequences adaptively
GLProbs is a simple and effective approach to improve the accuracy of multiple sequence alignment. We use a natural measure to estimate the similarity of the input sequences, and based on this measure, we align the input sequences differently. To test the effectiveness of this approach, we have implemented a multiple sequence alignment tool called GLProbs and compared its performance with a dozen leading alignment tools on three benchmark alignment databases, and GLProbs’s alignments has the best scores in almost all testings. ... -
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PANDA
Passing Attributes between Networks for Data Assimilation
PANDA (Passing Attributes between Networks for Data Assimilation), is a message-passing model to gene regulatory network reconstruction. PANDA integrates multiple sources of biological data, including protein-protein interaction, gene expression, and sequence motif information, in order to reconstruct genome-wide, condition-specific regulatory networks. PANDA is also available in other programming languages, including: MATLAB/Octave: (1) https://drive.google.com/a/channing.harvard.edu/file/d/0BwVdzX3nIj6RamtmNVdKYVk1N2c/view?... -
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FSA is a probabilistic multiple sequence alignment algorithm which uses a "distance-based" approach to aligning homologous protein, RNA or DNA sequences.
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RDP FrameBot is a frameshift correction and nearest neighbor classification tool for use with high-throughput amplicon sequencing. It uses a dynamic programming algorithm to align each query DNA sequence against a set of target protein sequences, produces frameshift-corrected protein and DNA sequences and an optimal global or local protein alignment. It also helps filter out non-target reads. The online version of FrameBot is available on http://fungene.cme.msu.edu/FunGenePipeline, tutorial http://rdp.cme.msu.edu/tutorials/framebot/RDPtutorial_FRAMEBOT.html. ...
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PlaTypUS
Plasmodium Typing Utility Software
The goal of PlaTypUS is to establish a unified Plasmodium whole genome analysis tool, that aligns short read sequences in an agreed upon manner, with many quality control steps, and calls both SNVs and CNVs in a community agreed standard way. We also seek to provide this analysis in a stand-alone graphic user interface so that labs around the world can analyze their own whole genome sequencing data, rather than relying on outside institutes. -
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DimerRemover
Remove adapter dimers from NGS data
This program can be used to count or remove adapter dimers in fastq files. Using a provided adapter sequence, it generates variations of this sequence and stores them in a hash table. The reads can then be directly matched against the hash. It is far more time efficient than doing alignment. -
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FineSplice
Enhanced splice junction detection and estimation from RNA-Seq data
Multiple mapping reads with a unique location after filtering are rescued and reallocated to the most reliable candidate location. FineSplice requires Python 2.x (>= 2.6) with the following modules installed: pysam (http://code.google.com/p/pysam/) and scikit-learn (http://scikit-learn.org/). For further details check out our publication: Nucl. -
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The sequence alignment task in MAGI (magi.ucsd.edu) is based on the miRanda algorithm, but we redesign the miRanda algorithm on GPU by taking its advantages of massively parallel computing and extra high memory bandwidth using using NVIDIA’s Compute Unified Device Architecture (CUDA). The CUDA-miRanda implementation is a fast microRNA target identification algorithm that aligns short nucleotide sequences (i.e., < 32 nucleotides) against longer reference sequences (e.g., 20k nucleotides). ...
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A protein alignment curation tool using Local Covariation from "Protein Sequence Alignment Analysis by Local Covariation: Coevolution Statistics Detect Benchmark Alignment Errors" by Dickson et al. published in PLoS ONE on June 8, 2012.
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Qudaich
Performs local sequence alignment for NGS data
Qudaich (queries and unique database alignment inferred by clustering homologs) is a software package for aligning sequences. Qudaich generates the pairwise local alignments between a query dataset against a database. The main design purpose of qudaich is to focus on datasets from next generation sequencing. These the datasets generally have hundreds of thousand sequences or more, and so, the input database should contain large number of sequences. Qudaich is flexible and its algorithmic... -
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ProGraphMSA
Graph-based multiple sequence alignment
ProGraphMSA is a state-of-the-art multiple sequence alignment tool which produces phylogenetically sensible gap patterns while maintaining robustness by allowing alternative splicings and errors in the branching pattern of the guide tree. This is achieved by incorporating a graph-based sequence representation as in POA and combines it with the advantages of the phylogeny-aware algorithm in Prank. -
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PhyloTreePruner
A nifty Java program for pruning phylogenetic trees.
...Single-gene trees are generated using the user’s preferred method. These trees are then provided to PhyloTreePruner which checks them for evidence of paralogy (i.e., multiple sequences from the same taxon that do not form a clade), trims suspected paralogs from the data matrix, and generates a new alignment containing only sequences inferred as orthologs. Preliminary tests of PhyloTreePruner on a variety of datasets indicate that this method successfully removes paralogous sequences and thus should help improve the accuracy of inferred species trees. -
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GenNon-h
Simulating non-homogeneous multiple sequence alignments
...Moreover, existing software restricts to the time-reversible models and it is not optimized to generate nonhomogeneous data (i.e. placing distinct substitution rates at different lineages). GenNon-H is the first package designed to generate multiple sequence alignments under the discrete-time Markov processes on phylogenetic trees, which samples directly from the transition matrices. Based on the input model and a phylogenetic tree in the Newick format (with branch lengths measured as the expected number of substitutions per site), the algorithm produces DNA alignments of desired length. ...
