Super Mario Python Final
A Space Master 2nd Edition Character Generator
Python/Pygame Game-Building Framework
Tactical, turn-based game engine, that uses OpenGL and WinAPI
Open source, moddable game engine for the "Polygon Love 2" game
Open Source Virtual World and MMOG Development Platform
MCManager - The ultimate Minecraft content manager.
Python Killboard Platform for EVE Online
A Python implementation of German Whist.
Soundtrack editor for Guild Wars 2
Entrepreneurship Training Program
Invaders like game, written in Python with Curses... :)