Super Mario Python Final
A Space Master 2nd Edition Character Generator
Python/Pygame Game-Building Framework
A 2D Elite-style game written in Python 3.2.
Tactical, turn-based game engine, that uses OpenGL and WinAPI
Open source, moddable game engine for the "Polygon Love 2" game
Open Source Virtual World and MMOG Development Platform
Conway's Game of Life and Turmites Combined!
The Quiz of Country and Their Capital.
Python Killboard Platform for EVE Online
Scriptable GTK based Python MUD Client
Invaders like game, written in Python with Curses... :)