Super Mario Python Final
Python/Pygame Game-Building Framework
A Space Master 2nd Edition Character Generator
Challenge the limit of your 3D imagination
A 2D Elite-style game written in Python 3.2.
Tactical, turn-based game engine, that uses OpenGL and WinAPI
Open source, moddable game engine for the "Polygon Love 2" game
Open Source Virtual World and MMOG Development Platform
Conway's Game of Life and Turmites Combined!
Open Source Breakout Clone
Python Killboard Platform for EVE Online
Scriptable GTK based Python MUD Client
Invaders like game, written in Python with Curses... :)
Make games with Lego-like building blocks