pfeMAME
Python front end for MAME that can run in Linux, Windows, and MacOS
pfeMAME is a front end for the Multiple Arcade Game Emulator (MAME) written in (wx)Python. It is cross platform (tested on Linux (Ubuntu), Windows (7, 8, 10, 11), and MacOS. ). It also includes a graphical Tile View designed for MAME cabinets which allows control using joystick / gamepad. It supports favourite game flagging, MESS systems, Software Lists (for systems), per-rom input mapping, and launching of other emulation engines. pfeMAME was written by Gareth Finch and the development project started in 2014 . The goal was to create a MAME front end that was simple, as easy as possible to get into, and had some good documentation. It doesn't provide access to every single MAME option, but pretty much all of the relevant ones you will use from day-to-day.
You are free to distribute pfeMAME and modify its source as you wish, however pfeMAME is not to be sold or repackaged for commercial sale.