DownloadSPINA is software for determining constant structure parameters of endocrine feedback control systems from hormone levels obtained in vivo.
The first version of this cybernetic approach allows for evaluating the functional status of the thyroid gland, i.e. thyroid's secretory capacity (GT or SPINA-GT) and sum activity of peripheral deiodinases (GD or SPINA-GD).
A second version has been developed for insulin-glucose homeostasis. It delivers the secretory capacity of pancreatic beta cells (SPINA-GBeta), an estimate for the insulin receptor gain (SPINA-GR) and a static disposition index as a measure for the loop gain of the feedback loop (SPINA-DI).
Both implementations of SPINA have been validated in clinical studies on the basis of large cohorts.
Features
- More than 25 years of continued development
- Based on published parametrically isomorphic model of thyroid and insulin-glucose homeostasis
- Algorithm evaluated in multiple clinical trials with thousands of patients
- Suport for different units of measurement
- Data import and export in HL7 format
- Curated by SciScrunch, OpenAIRE and Zenodo
- Cross-platform for Mac OS Classic, macOS (Mac OS X), Windows, Linux and Palm OS / Garnet OS
- DOI 10.5281/zenodo.3596049 https://doi.org/10.5281/zenodo.3596049
Project Samples
License
BSD LicenseUser Reviews
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Uses this tool to get a more specific view of thyroid data - very nice tool
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Spina works great.