Unpack the zip archive into any web accessible folder on your server.
You will need to have read/write access to leaders.xml (chmod 775).
Import res/acronyms.sql into MySQL using a tool like PhpMyAdmin.
Change the variables in classes/config.class.php to the desired settings.
To create your own questions and answers, edit res/questionsandanswers.php as desired.
Navigate to the folder where you unpacked the zip file in your browser and it should just work.