#54 Kroes TTC daily intake

[Nina Jeliazkova]

The implementation works well with daily intake below 1000 µg/d. Entering
daily intakes larger than 999 µg/d the implementation gives you the
message, that
QQ5.Does estimated intake exceed TTC of 1.5 µg/day ? No - What is wrong,
thus intakes exceeding Cramer Class I (1800 µg/d) can not be judged.

[Nina Jeliazkova]

Fixed in https://sourceforge.net/p/toxtree/svn/1770/ (toxtree-3.0.0-SNAPSHOT)

[Pierpaolo]

what is the right value to enter in daily intake when the KROES TTC DECISION TREE is running?
for example : C=CC(=O)N ----> QQ4.Does estimated intake exceed TTC of 0.15 µg/day ? " I enter 0,2 or 0,9 and the system's outcome is
"No ,Class Negligible risk (low probability of a life-time cancer risk greater than 1 in 10^6")

does The tool recognize value with expressed as 0,1 but consider 0.1 (point) as 1?
How should I enter value to get a daily intake over 1800mcg/day in kroes ttc decision tree?
For example: the molecule CC1=CCC(CC1)C(=C)C
if I enter 3000 mcg/day as intake the model's outcome is  QQ12.Does estimated intake exceed 1800 µg/day ? No Class Substance would not be expected to be a safety concern CC1=CCC(CC1)C(=C)C.

thank you

[Pierpaolo]

in addition to the example above, the value of 3000 is converted to 3.000 that means as 3!!

[Nina Jeliazkova]

Fixed in Toxtree 3.1.0
https://sourceforge.net/projects/toxtree/files/toxtree/Toxtree-v.3.1.0/