SimThyr has been updated to version 3.3.3. This bug-fix release addresses two issues affecting the editor for structure parameters.
SimThyr 3.3.3 is available from http://simthyr.sf.net for Mac OS X, Windows and Linux.
Two recent research papers suggest that an additional mechanism might control T3 secretion in humans. Integration of in silico-analyses with SimThyr and observation of data of more than 1000 patients with and without substitution therapy with levothyroxine (L-T4) gave new hints that in humans TSH might stimulate deiodinase activity in vivo.
It is known for long time that cAMP up-regulates both type 1 and type 2 deiodinase, and it could also be shown that TSH (which uses cAMP as second messenger) is able to stimulate deiodination, but these observations resulted from animal experiments and cell culture investigations only. It was unknown if they are of any relevance in humans and on the level of the whole organism.... read more
SimThyr 3.3.1 has been released. This is a bug fix release that addresses several stability issues affecting file handling, two-way sensitivity analysis and GUI functionality.
The new version that is recommended for all users of SimThyr is available from http://simthyr.sf.net .
As accompanying software of a series of lectures on internal medicine, SimThyr has received the eLearning Label of the Ruhr University of Bochum. See https://twitter.com/SimThyrTeam/status/492046768998449152 for details.
On the occasion of the World Thyroid Day we have released SimThyr 3.3.
The new version introduces significant new features, first of all support for two-way sensitivity analysis. This technique allows for studying the combined effect of two structural parameters on a behavioural parameter (i.e. hormone level). Additionally, SimThyr 3.3 adopts version handling for scenario files, an option to switch off the circadian TRH rhythm and more flexible handling of units of measurement based on PUMA Repository, Last but not least some bugs have been fixed.... read more
SimThyr has been published in version 3.2.4. This is a hot-fix release that addresses the tracker items #18 ("Scenario files are not correctly read in") and #19 ("Windows: Text in help window too small to be read").
We are glad to announce that SimThyr has been released in version 3.2.3 today. This is a bug-fix release that addresses numerous issues including the tracker items #12 to #17. Additionally, SimThyr 3.2.3 is the first version that has been code-signed for Mac OS X. This makes it easier to install the application on newer versions of Mac OS X, including Lion, Mountain Lion and Mavericks.
A bug fix release, SimThyr 3.2.2, has been made available at sourceforge.net. As this version addresses some major issues it is highly recommended to update your existing installation.
SimThyr 3.2.2 is available for Mac OS X, Windows and Linux. Please visit http://simthyr.sf.net to get your update for free.