[Marsbar-users] Amplification of central response demonstrated by signal change ?

[CarlosTseng <tm...@gm...>]

Hi all,
 
Herein I have a question about ROI which has puzzled me for a long time.
 
In controls (CTL) and patients (PT), I used MarsBaR to extract the percent
signal change (%SC) in several ROI, including the thalamus (Th) and primary
somatosensory cortex (S1).
 
In ROI analysis, my aim is to test the hypothesis that somatosensory signal
relayed from Th is further amplified when arriving in S1.
 
Before that, I've already found that the %SC of Th to somatosensory
stimulation in PT is significantly greater than that in CTL, suggesting that
neural response in Th is enhanced in PT.  

Then, I want to know if the response in S1 is further enhanced relative to
Th in PT, along the Th-S1 pathway. The idea is to demonstrate the
neuroimaging evidence that cerebral response is further augmented while
signaling in the somatosensory pathway.
 
The following is my method:

I first calculated the difference (increase) of %SC between Th and S1 (S1
minus Th) in CTL and PT. If the difference (increase) is greater in PT than
that in CTL, I can say that, in PT, the response is not only enhanced in Th,
but is further amplified while relaying from Th to S1.
 
Does my logic make sense? 

I appreciate for any help.
 
Carlos
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