does genocide affect quest leaders/nemesis?

If I were to genocide humans it would automaticly block me from genociding my quest leader or shopkeepers or etc
But what if my nemesis or a unique named monster in a new quest was a Lich or a Nymph or a Mumak even. Would the game automatically block genocide or would I need to use one of the flags in monst.c to insure that you cannot genocide it?

I feel like I am asking too many questions here...
Is there somewhere else I should post the questions I have posted?