Best Large Language Models for Claude Science
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Compare the Top Large Language Models that integrate with Claude Science as of July 2026
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This a list of Large Language Models that integrate with Claude Science. Use the filters on the left to add additional filters for products that have integrations with Claude Science. View the products that work with Claude Science in the table below.
What are Large Language Models for Claude Science?
Large language models are artificial neural networks used to process and understand natural language. Commonly trained on large datasets, they can be used for a variety of tasks such as text generation, text classification, question answering, and machine translation. Over time, these models have continued to improve, allowing for better accuracy and greater performance on a variety of tasks. Compare and read user reviews of the best Large Language Models for Claude Science currently available using the table below. This list is updated regularly.
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1
Claude Opus 4.7
Anthropic
Claude Opus 4.7 is the latest Anthropic AI model release designed to significantly improve performance in advanced software engineering and complex problem-solving tasks. It builds upon the previous Opus 4.6 model by delivering stronger results on difficult coding challenges and long-running workflows. The model is known for its ability to follow instructions precisely and verify its own outputs for greater reliability. It also introduces enhanced multimodal capabilities, particularly in processing high-resolution images with improved accuracy. Opus 4.7 supports more detailed visual tasks such as analyzing dense screenshots and extracting data from complex diagrams. In professional settings, it produces higher-quality outputs including documents, presentations, and user interfaces. The model includes updated safety features that detect and block high-risk cybersecurity-related requests.Starting Price: $5 per million tokens (input) -
2
Claude Opus 4.8
Anthropic
Claude Opus 4.8 is a powerful AI model from Anthropic designed to deliver stronger coding, reasoning, agentic workflows, and advanced collaboration capabilities for developers, enterprises, and AI-powered productivity tasks. The model builds on Claude Opus 4.7 with improvements across coding benchmarks, practical knowledge work, alignment, and reliability while maintaining the same pricing structure. Claude Opus 4.8 introduces enhanced honesty and reasoning behavior, making it less likely to generate unsupported claims or overlook flaws during complex tasks such as software development and agent execution. The release also includes new features such as effort control settings, fast mode for lower-cost high-speed processing, and dynamic workflows in Claude Code that allow the system to coordinate hundreds of parallel subagents for large-scale tasks.Starting Price: $5 per 1M (input) -
3
Claude Fable 5
Anthropic
Claude Fable 5 is an advanced AI model from Anthropic designed to assist with software engineering, research, knowledge work, vision tasks, and complex reasoning. Built on the Mythos-class architecture, it delivers significantly improved performance across coding, analysis, and long-context workflows. The model can handle extended autonomous tasks while maintaining focus and consistency over large amounts of information. Claude Fable 5 integrates advanced reasoning, multimodal understanding, and memory capabilities to support professional and enterprise use cases. Anthropic has implemented specialized safeguards that automatically route certain high-risk cybersecurity, biology, chemistry, and model distillation requests to a different model. Claude Fable 5 helps organizations and professionals accelerate complex work while maintaining strong safety and governance controls.Starting Price: $10 per 1 million (input) -
4
Claude Mythos 5
Anthropic
Claude Mythos 5 is Anthropic’s most advanced restricted-access AI model, designed for trusted cyberdefenders, infrastructure providers, and select research organizations. It uses the same underlying model as Claude Fable 5 but provides lifted safeguards in approved areas for specialized high-trust use cases. The model delivers exceptional capabilities in cybersecurity, software engineering, scientific research, long-context reasoning, vision, and autonomous task execution. Anthropic initially deployed Claude Mythos 5 through Project Glasswing in collaboration with the U.S. government to help protect critical software and infrastructure. The model also shows strong potential in life sciences, including protein design, molecular biology hypothesis generation, and genomics research. Claude Mythos 5 is built for organizations that need frontier AI capabilities under controlled, trusted-access conditions.Starting Price: $10 per 1 million (input) -
5
Claude Opus 4.6
Anthropic
Claude Opus 4.6 is an advanced AI model developed by Anthropic, designed for high-level reasoning, coding, and knowledge work tasks. It introduces significant improvements in coding, debugging, and code review capabilities. The model can handle long, complex workflows and sustain agentic tasks with greater reliability. It features a 1 million token context window in beta, enabling it to process and retain large amounts of information. Claude Opus 4.6 is optimized for tasks such as financial analysis, research, and document creation. It also integrates with tools like Excel and PowerPoint for enhanced productivity. Overall, it is a state-of-the-art AI model built for complex, real-world professional applications. -
6
Claude Sonnet 4.6
Anthropic
Claude Sonnet 4.6 is Anthropic’s most advanced Sonnet model to date, delivering significant upgrades across coding, computer use, long-context reasoning, agent planning, and knowledge work. It introduces a 1 million token context window in beta, allowing users to analyze entire codebases, lengthy contracts, or large research collections in a single session. The model demonstrates major improvements in instruction following, consistency, and reduced hallucinations compared to previous Sonnet versions. In developer testing, users strongly preferred Sonnet 4.6 over Sonnet 4.5 and even favored it over Opus 4.5 in many coding scenarios. Its enhanced computer-use capabilities enable it to interact with real software interfaces similarly to a human, improving automation for legacy systems without APIs. Sonnet 4.6 also performs strongly on major benchmarks, approaching Opus-level intelligence at a more accessible price point. -
7
Claude Opus 4.1
Anthropic
Claude Opus 4.1 is an incremental upgrade to Claude Opus 4 that boosts coding, agentic reasoning, and data-analysis performance without changing deployment complexity. It raises coding accuracy to 74.5 percent on SWE-bench Verified and sharpens in-depth research and detailed tracking for agentic search tasks. GitHub reports notable gains in multi-file code refactoring, while Rakuten Group highlights its precision in pinpointing exact corrections within large codebases without introducing bugs. Independent benchmarks show about a one-standard-deviation improvement on junior developer tests compared to Opus 4, mirroring major leaps seen in prior Claude releases. -
8
Claude Sonnet 4.5
Anthropic
Claude Sonnet 4.5 is Anthropic’s latest frontier model, designed to excel in long-horizon coding, agentic workflows, and intensive computer use while maintaining safety and alignment. It achieves state-of-the-art performance on the SWE-bench Verified benchmark (for software engineering) and leads on OSWorld (a computer use benchmark), with the ability to sustain focus over 30 hours on complex, multi-step tasks. The model introduces improvements in tool handling, memory management, and context processing, enabling more sophisticated reasoning, better domain understanding (from finance and law to STEM), and deeper code comprehension. It supports context editing and memory tools to sustain long conversations or multi-agent tasks, and allows code execution and file creation within Claude apps. Sonnet 4.5 is deployed at AI Safety Level 3 (ASL-3), with classifiers protecting against inputs or outputs tied to risky domains, and includes mitigations against prompt injection. -
9
Claude Opus 4.5
Anthropic
Claude Opus 4.5 is Anthropic’s newest flagship model, delivering major improvements in reasoning, coding, agentic workflows, and real-world problem solving. It outperforms previous models and leading competitors on benchmarks such as SWE-bench, multilingual coding tests, and advanced agent evaluations. Opus 4.5 also introduces stronger safety features, including significantly higher resistance to prompt injection and improved alignment across sensitive tasks. Developers gain new controls through the Claude API—like effort parameters, context compaction, and advanced tool use—allowing for more efficient, longer-running agentic workflows. Product updates across Claude, Claude Code, the Chrome extension, and Excel integrations expand how users interact with the model for software engineering, research, and everyday productivity. Overall, Claude Opus 4.5 marks a substantial step forward in capability, reliability, and usability for developers, enterprises, and end users.
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