Microsoft Defender for Business vs. OPSWAT MetaDefender Comparison Chart

ManageEngine Endpoint Central is built to secure the digital workplace while also giving IT teams complete control over their enterprise endpoints. It delivers a security-first approach by combining advanced endpoint protection with comprehensive management, allowing IT teams to manage the entire endpoint lifecycle, all from a single console. With automated patching across Windows, Mac, Linux and 1,000+ third-party applications, it ensures vulnerabilities are mitigated before attackers can exploit them. Its next-gen antivirus (NGAV) feature, powered by AI-driven behavioural detection, provides 24/7 protection against ransomware, malware, and zero-day threats. Endpoint Central further strengthens enterprise defenses with a broad set of security capabilities, including vulnerability assessment and mitigation, peripheral device control, data loss prevention, application control, endpoint privilege management, encryption with FileVault and BitLocker, and browser security.

ESET Protect Advanced is a comprehensive cybersecurity solution designed for businesses of all sizes. It offers advanced endpoint protection against ransomware, zero-day threats, and sophisticated attacks with ESET LiveSense technology. It includes full disk encryption for legal compliance and data protection. The solution features proactive cloud-based threat defense using adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis to prevent new threats. Mobile threat defense secures Android and iOS devices with anti-malware, anti-theft, and mobile device management. It also provides cloud app protection, mail server security, and vulnerability and patch management. Extended detection and response (XDR) enhances threat detection and response, while multi-factor authentication adds security. The solution offers single-pane-of-glass remote management for visibility into threats and users, along with advanced reporting and custom notifications.

ConnectWise SIEM (formerly Perch) offers threat detection and response backed by an in-house Security Operations Center (SOC). Defend against business email compromise, account takeovers, and see beyond your network traffic. Our team of threat analysts does all the tedium for you, eliminating the noise and sending only identified and verified treats to action on. Built with multi-tenancy, ConnectWise SIEM helps you keep clients safe with the best threat intel on the market.

Cyber threats are everywhere, but protecting your IT systems should be as natural as locking your front door. With DriveLock’s HYPERSECURE Platform, safeguarding your endpoints and business data is easier than ever. We integrate the latest security technologies and share our expertise, so you can focus on what matters—without worrying about data protection. Zero Trust Platform takes a proactive approach, eliminating security gaps before they become a risk. By enforcing centralized policies, DriveLock ensures employees and endpoints access only what they need—following the golden rule of cybersecurity: ''never trust, always verify''.

Bitdefender Small Business Security delivers enterprise-grade, layered cyber-protection designed specifically for small organizations. It covers Windows, macOS, iOS, and Android devices with centralized, easy-to-use management, so businesses without a dedicated IT staff can deploy and monitor security from one dashboard. Key features include multi-layered endpoint protection (machine learning, behavioral analytics, real-time monitoring, process termination, and rollback) to prevent known and unknown threats. It offers ransomware prevention and mitigation (detecting abnormal encryption attempts and restoring files from backups), fileless attack protection (memory/back-injection interference, script blocking), phishing & fraud prevention (blocking deceptive sites and warning users), and advanced exploit protection (real-time shield of browsers, Office apps, Adobe Reader) for comprehensive endpoint defense.

Guardz is the unified cybersecurity platform purpose-built for MSPs. We consolidate the essential security controls, including identities, endpoints, email, awareness, and more, into one AI-native framework designed for operational efficiency. Our identity-centric approach connects the dots across vectors, reducing the gaps that siloed tools leave behind so MSPs can see, understand, and act on user risk in real time. Backed by an elite research and threat hunting team, Guardz strengthens detection across environments, turning signals into actionable insights. With 24/7 AI + human-led MDR, Guardz utilizes agentic AI to triage at machine speed while expert analysts validate, mitigate, and guide response, giving MSPs scalable protection without adding headcount. Our mission is simple: give MSPs the scale, confidence, and clarity they need to stay ahead of attackers and deliver protection to every SMB they serve.

DriveStrike is easy to use, implement and manage. With DriveStrike you can execute secure remote wipe, remote lock, and remote locate commands on any platform. Integrated drive encryption support as well as mobile device management MDM for mobile platforms. Our professional support team is always available to answer your questions and help you install our services or manage your account and devices. Protecting your data and devices has never been easier or more cost effective. If you have questions or need help understanding how best to protect your data please contact us and we will gladly answer your questions. Protect your business with a device and data protection platform that keeps all devices safe with a single solution and Dashboard. Keep your Workstations, MacBooks, iPads, Smartphones, Tablets, Laptops safe, secure, and organized.

The ThreatLocker suite of security tools are powerful and designed so that everyone from businesses to government agencies to academic institutions can directly control exactly what applications run on their networks. We envision a future in which all organizations can chart their own course free from the influence of cybercriminals and the damage their incursions cause, and our team of veteran cybersecurity professionals created ThreatLocker to make this vision a reality. The team at ThreatLocker has been developing cybersecurity tools for decades, including programs to enhance email and content security, and this is our most innovative and ambitious cybersecurity solution yet. We developed this unique cybersecurity system because we believe that organizations should have complete control of their networks and should not have to live in fear of the next malware attack. To learn more, visit ThreatLocker.com.

NinjaOne unifies IT to simplify work for 35,000+ customers in 140+ countries. The NinjaOne Unified IT Operations Platform delivers endpoint management, autonomous patching, backup, and remote access in a single console to improve efficiency, increase resilience, and reduce spend. By automating IT and managing all endpoints, organizations give employees a great technology experience to work faster, smarter, and easier while IT teams modernize and improve efficiency. NinjaOne is a Leader in the Gartner Magic Quadrant for Endpoint Management Tools. The company is obsessed with customer success and has retained a 98% customer satisfaction score for more than 5 years.

Safetica’s Intelligent Data Security protects sensitive data where teams work, using powerful AI to deliver contextual awareness, reduce false positives, and stop real threats without disrupting productivity. With Safetica, security teams can maintain visibility and control over sensitive data, stay ahead of insider risks, maintain compliance, and secure sensitive cloud-based data. ✔️ Data Protection: Classify, monitor and control sensitive data across devices and clouds in real time. ✔️ Insider Risk and User Behavior: Spot risky behavior, detect intent, and stop insider threats to stay ahead of the careless handling of sensitive data, compromised user accounts and malicious user activity. ✔️ Compliance and Data Discovery: Prove compliance with audit-ready reporting for data in use, in motion, and at rest. ✔️ Cloud Security: Protect Microsoft 365, cloud, and file-sharing platforms to secure sensitive cloud-based data.