Claude Mythos 5

Claude Mythos 5

Anthropic
ESMC

ESMC

Biohub
+
+

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About

Claude Mythos 5 is Anthropic’s most advanced restricted-access AI model, designed for trusted cyberdefenders, infrastructure providers, and select research organizations. It uses the same underlying model as Claude Fable 5 but provides lifted safeguards in approved areas for specialized high-trust use cases. The model delivers exceptional capabilities in cybersecurity, software engineering, scientific research, long-context reasoning, vision, and autonomous task execution. Anthropic initially deployed Claude Mythos 5 through Project Glasswing in collaboration with the U.S. government to help protect critical software and infrastructure. The model also shows strong potential in life sciences, including protein design, molecular biology hypothesis generation, and genomics research. Claude Mythos 5 is built for organizations that need frontier AI capabilities under controlled, trusted-access conditions.

About

ESMC is the latest in the ESM family of protein language models, establishing a new frontier in representation learning for protein biology. Trained on billions of evolutionary sequences, it learns representations that reflect a mechanistic reduction of protein structure and function. The model is built on a transformer architecture, supports sequences as its core modality, and is trained on up to 6 billion proteins. ESMC is designed for protein science research, including structure prediction, function annotation, protein design, and understanding evolutionary relationships between proteins. It can generate novel proteins from partial sequence, structure, or functional constraints, helping researchers explore new possibilities in protein design and biological discovery. The Biohub Platform provides access to ESMC through the API and the ESM Python package, with quickstart resources for installing the package, creating an API key, connecting to the platform.

Platforms Supported

Windows
Mac
Linux
Cloud
On-Premises
iPhone
iPad
Android
Chromebook

Platforms Supported

Windows
Mac
Linux
Cloud
On-Premises
iPhone
iPad
Android
Chromebook

Audience

Claude Mythos 5 is designed for cyberdefense teams, critical infrastructure providers, government partners, biomedical researchers, life sciences organizations, advanced AI research teams, and trusted enterprises that need restricted access to frontier AI capabilities

Audience

Protein science researchers who need transformer-based sequence representations for structure prediction, function annotation, mutation analysis, and protein design

Support

Phone Support
24/7 Live Support
Online

Support

Phone Support
24/7 Live Support
Online

API

Offers API

API

Offers API

Screenshots and Videos

Screenshots and Videos

Pricing

$10 per 1 million (input)
Free Version
Free Trial

Pricing

Free
Free Version
Free Trial

Reviews/Ratings

Overall 5.0 / 5
ease 5.0 / 5
features 5.0 / 5
design 5.0 / 5

Reviews/Ratings

Overall 0.0 / 5
ease 0.0 / 5
features 0.0 / 5
design 0.0 / 5
support 0.0 / 5

This software hasn't been reviewed yet. Be the first to provide a review:

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Training

Documentation
Webinars
Live Online
In Person

Training

Documentation
Webinars
Live Online
In Person

Company Information

Anthropic
Founded: 2023
United States
claude.ai

Company Information

Biohub
Founded: 2016
United States
biohub.ai/models/esmc

Alternatives

Claude Fable 5

Claude Fable 5

Anthropic

Alternatives

Claude Opus 4.7

Claude Opus 4.7

Anthropic
Evo 2

Evo 2

Arc Institute
Claude Opus 4.8

Claude Opus 4.8

Anthropic
ESMFold2

ESMFold2

Biohub
Claude Mythos

Claude Mythos

Anthropic
Claude Sonnet 5

Claude Sonnet 5

Anthropic
HyperProtein

HyperProtein

Hypercube

Categories

Categories

Integrations

Python
BLACKBOX AI
Buda
CSS
Cherry Studio
Claude Cowork
Claude Pro
Claw Code
Devin Desktop
Lua
Model Context Protocol (MCP)
OpenClaw.Direct
PHP
PowerShell
RustRover
Scalestack
Snowflake Cortex AI
Trinity-Large-Thinking
Visual Basic
Xcode

Integrations

Python
BLACKBOX AI
Buda
CSS
Cherry Studio
Claude Cowork
Claude Pro
Claw Code
Devin Desktop
Lua
Model Context Protocol (MCP)
OpenClaw.Direct
PHP
PowerShell
RustRover
Scalestack
Snowflake Cortex AI
Trinity-Large-Thinking
Visual Basic
Xcode
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