The purpose of the current project is the development of a potentially open-source platform that would provide the capability to conduct virtual bioequivalence trial simulations. Ideally, this user-friendly platform will provide the user with many user-defined capabilities.
Algorithm implementation for population pharmacokinetic analysis: The current project describes the marriage between PBPK modeling and population-based statistical analysis. The latter is necessary for parameter estimation when individual-level data is available. A critical aspect of this coupling is the implementation of an algorithm that would allow the performance of population-based statistical analysis. Although novelty is encouraged in regards to the algorithm, proposals could entertain approaches such as: a. Implementing the non-linear mixed effects theory, b. Maximum log-likelihood algorithms (stiff, non-stiff Ordinary Differential Equation solving methods with linearization)
vBioE2
Status: Alpha
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