TSMiner

TSMiner is a software program for reconstructing time-specific regulatory networks for time-series expression data. TSMiner has three key modules: first, predicting the time-specific activated/repressed transcription factors (TFs); second, predicting the biological pathways associated with the predicted TFs; third, merging the TFs and pathways into time-specific regulatory networks. TSMiner provides extensive interactive operations to help users explore the results of each module. For example, we made use of the tree structure map developed by the Dynamic Regulatory Events Miner (DREM) (Ernst et al. 2007) to show the time-specific TFs. And we developed an interactive network map to help users explore the time-specific regulatory networks.