SEM_bestShortestPath

SEM_bestShortestPath is a Structural Equation Modeling (SEM)-based methodology to evaluate the most important shortest paths between differentially expressed genes in biological interaction networks, with absolutely no need of user-defined parameters or heuristic rules, enabling a free-of-bias discovery and overcoming common issues affecting recent network-based algorithms. SEM-bsp is based on Structural Equation Modeling techniques to detect significantly perturbed sub-networks (disease modules) from microarray data, relevant for the disease phenotype under investigation.