This is the protein similarity network - PSIN. Here, the nodes are human proteins and they are linked only if they share considerable sequence similarity.

We found that this network is particularly useful to distinguish approved from problematic drug-targets.

Here you also find the complete set of programs and datasets we used for this purpose.

Free to help further test and develop this project. Your help and expertise are much appreciated !

If you have any questions, please do not hesitate to contact us in the forum or by email.

Please see the original manuscript:

Lopes, TJS, et al. (2015) - "Identifying problematic drugs based on the characteristics of their targets" - Frontiers in Pharmacology doi: 10.3389/fphar.2015.00186

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Creative Commons Attribution ShareAlike License V3.0, GNU General Public License version 3.0 (GPLv3)

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Additional Project Details

Operating Systems

Linux, Mac, Windows

Intended Audience

Advanced End Users, Healthcare Industry, Science/Research

Programming Language

Java, Perl, S/R

Related Categories

Perl Molecular Science Software, Perl Bio-Informatics Software, Perl Medical Software, Java Molecular Science Software, Java Bio-Informatics Software, Java Medical Software, S/R Molecular Science Software, S/R Bio-Informatics Software, S/R Medical Software

Registered

2014-02-07