O2 pathway and ROS generation model download

The production of reactive oxygen species (ROS) from the inner mitochondrial membrane is one of many fundamental processes governing the balance between health and disease. It is well known that ROS are necessary signaling molecules in gene expression, yet when expressed at high levels, ROS may cause oxidative stress and cell damage. Both hypoxia and hyperoxia may alter ROS production by changing mitochondrial PO2 (PmO2). This graphical user interface facilitates to parameterize and simulate an integrative mathematical model of O2 transport and utilization in skeletal muscle to predict conditions under which PmO2 might fall enough to cause abnormally high ROS generation.
For further details please see http://www.ncbi.nlm.nih.gov/pubmed/25375931.

Features

O2 pathway simulation
ROS generation predictions
Lung functional heterogeneities
Tissue inhomogeneities

Project Samples

Main Graphical User Interface (GUI) for managing the O2 pathway simulation output

Main Graphical User Interface (GUI) for managing the ROS prediction model simulation output

Graphical User Interface (GUI) for managing the O2 pathway lung functional heterogeneities input parameters

Graphical User Interface (GUI) for managing the O2 pathway tissue heterogeneities input parameters

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