The Modular Single-set Enrichment Test (MSET) is a randomization testing script written in R that allows the user to statistically assess overrepresentation of any gene list of interest within a list of significant gene results from an expression study.
MSET uses a tcltk graphical user interface and is optimized for use in Windows operating systems. It also works in OS X, but requires the installation of the XQuartz architecture (https://xquartz.macosforge.org/trac/wiki) to enable tcltk. This added complexity can lead to technical difficulties.
UPDATE: An MSET script ("mset_text.R") is now included in the MSET folder which allows users to manually designate input files via a text prompt. This bypasses the need for tcl/tk on OS X, although it is not as fast or easy to use. File names must be entered in quotations, including the .txt extension, and are case sensitive.
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